2006
Actin polymerization regulates clathrin coat maturation during early stages of synaptic vesicle recycling at lamprey synapses
Bourne J, Morgan JR, Pieribone VA. Actin polymerization regulates clathrin coat maturation during early stages of synaptic vesicle recycling at lamprey synapses. The Journal Of Comparative Neurology 2006, 497: 600-609. PMID: 16739194, DOI: 10.1002/cne.21006.Peer-Reviewed Original Research
2003
Colocalization of synapsin and actin during synaptic vesicle recycling
Bloom O, Evergren E, Tomilin N, Kjaerulff O, Löw P, Brodin L, Pieribone VA, Greengard P, Shupliakov O. Colocalization of synapsin and actin during synaptic vesicle recycling. Journal Of Cell Biology 2003, 161: 737-747. PMID: 12756235, PMCID: PMC2199372, DOI: 10.1083/jcb.200212140.Peer-Reviewed Original ResearchConceptsSynaptic activityEndocytic zonesSynaptic vesicle recyclingSynaptic vesicle clustersMature nerve terminalsPool of vesiclesNerve terminalsActive synapsesGiant synapseVesicle recyclingAvailability of vesiclesSynapsin immunoreactivitySynaptic vesiclesVesicle clustersProminent reductionSynapsinSynapses
2000
Multiple messengers in descending serotonin neurons: localization and functional implications
Hökfelt T, Arvidsson U, Cullheim S, Millhorn D, Nicholas A, Pieribone V, Seroogy K, Ulfhake B. Multiple messengers in descending serotonin neurons: localization and functional implications. Journal Of Chemical Neuroanatomy 2000, 18: 75-86. PMID: 10708921, DOI: 10.1016/s0891-0618(99)00037-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCatsGamma-Aminobutyric AcidHaplorhiniMedulla OblongataNeuronsNeuropeptidesRatsSerotoninSpinal CordConceptsGamma-amino butyric acidSerotonin neuronsInhibitory neurotransmitter gamma-amino butyric acidNeurotransmitter gamma-amino butyric acidRaphe serotonin neuronsPost-synaptic actionsParticular substance PNumber of neuropeptidesSerotonin projectionsDorsal hornVentral hornSubstance PSpinal cordSame neuronsRostral levelsSuch neuronsNeuronsEnzyme glutaminasePresent review articleGlutamateRecent studiesReview articleFunctional implicationsWide spectrumHorn
1999
Inhibition of neurotransmitter release in the lamprey reticulospinal synapse by antibody-mediated disruption of SNAP-25 function
Low P, Norlin T, Risinger C, Larhammar D, Pieribone V, Shupliakov O, Brodin L. Inhibition of neurotransmitter release in the lamprey reticulospinal synapse by antibody-mediated disruption of SNAP-25 function. European Journal Of Cell Biology 1999, 78: 787-793. PMID: 10604655, DOI: 10.1016/s0171-9335(99)80029-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAxonsCell MembraneImmunohistochemistryIn Situ HybridizationLampreysMembrane ProteinsMicroinjectionsMicroscopy, ElectronNerve Tissue ProteinsNeurotransmitter AgentsProtein BindingRecombinant Fusion ProteinsSpinal CordSynapsesSynaptic TransmissionSynaptic VesiclesSynaptosomal-Associated Protein 25ConceptsPlasma membraneSynaptic vesiclesSNAP-25Lamprey giant reticulospinal synapsePresynaptic plasma membraneSynaptic vesicle exocytosisLamprey reticulospinal synapseSNARE protein SNAP-25Protein SNAP-25Synaptic vesicle clustersNeurotransmitter releaseSNARE complexMolecular machineryVesicle exocytosisMembrane fusionVesicle cyclingPresynaptic microinjectionVesicle clustersSyntaxinPresynaptic membraneVesiclesElectron microscopic analysisAntibody-mediated disruptionMembraneMicroscopic analysis
1995
Distinct pools of synaptic vesicles in neurotransmitter release
Pieribone V, Shupliakov O, Brodin L, Hilfiker-Rothenfluh S, Czernik A, Greengard P. Distinct pools of synaptic vesicles in neurotransmitter release. Nature 1995, 375: 493-497. PMID: 7777058, DOI: 10.1038/375493a0.Peer-Reviewed Original ResearchConceptsNeurotransmitter releaseCellular secretory systemSynaptic vesiclesLow-frequency stimulationSynaptic release sitesRelease of neurotransmittersHigh-frequency burstsNeuron-specific proteinSynapsin antibodiesPool of vesiclesDistal poolNerve terminalsMarked depressionVesicular releasePresynaptic membraneSynapsinHigh rateClusters of vesiclesApparent effectReleaseSecretory systemSuch protein familiesNeurotransmittersRelease sitesSynaptic Vesicle Depletion in Reticulospinal Axons is Reduced by 5‐hydroxytryptamine: Direct Evidence for Presynaptic Modulation of Glutamatergic Transmission
Shupliakov O, Pieribone VA, Gad H, Brodin L. Synaptic Vesicle Depletion in Reticulospinal Axons is Reduced by 5‐hydroxytryptamine: Direct Evidence for Presynaptic Modulation of Glutamatergic Transmission. European Journal Of Neuroscience 1995, 7: 1111-1116. PMID: 7613617, DOI: 10.1111/j.1460-9568.1995.tb01099.x.Peer-Reviewed Original ResearchConceptsReticulospinal axonsPresynaptic Ca2Glutamatergic synaptic transmissionSynaptic glutamate releaseSynaptic vesiclesIntra-axonal recordingsGiant reticulospinal axonsSynaptic vesicle clustersGlutamatergic transmissionPresynaptic modulationGlutamate releaseSpinal cordPresynaptic elementsSynaptic transmissionAction potential stimulationSynaptic vesicle depletionSame axonVesicle depletionAxonsMarked reductionNumber of vesiclesPotential stimulationSynaptic exocytosisActive zoneCa2Chapter 4 Peptidergic neurons in the vertebrate spinal cord: evolutionary trends
Brodin L, Söderberg C, Pieribone V, Larhammar D. Chapter 4 Peptidergic neurons in the vertebrate spinal cord: evolutionary trends. Progress In Brain Research 1995, 104: 61-74. PMID: 8552784, DOI: 10.1016/s0079-6123(08)61784-7.Peer-Reviewed Original ResearchConceptsVertebrate spinal cordEarly vertebratesVertebrate classesDifferent vertebratesPeptidergic neuronsMutational eventsVertebrate CNSEvolutionary trendsVertebratesPeptide sequencesMammalian CNSMammalsComprehensive comparative analysisSpeciesFour questionsMolecular featuresCertain CNS regionsTarget cellsAnatomical featuresLater stagesAnatomical differencesCyclostomesCNS regionsEvolutionNeurons
1994
The reticulospinal glutamate synapse in lamprey: plasticity and presynaptic variability
Brodin L, Shupliakov O, Pieribone VA, Hellgren J, Hill RH. The reticulospinal glutamate synapse in lamprey: plasticity and presynaptic variability. Journal Of Neurophysiology 1994, 72: 592-604. PMID: 7983521, DOI: 10.1152/jn.1994.72.2.592.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsReticulospinal axonsAction potentialsPulse stimulationSynaptic areaBody stimulationElectrotonic componentUse-dependent modulationAxonal action potentialsSecond action potentialDifferent postsynaptic cellsGiant reticulospinal axonsNet facilitationSpinal neuronsPostsynaptic potentialsEPSP componentsGlutamatergic synapsesPresynaptic elementsSynaptic responsesPresynaptic axonsTransmitter releaseGlutamate synapsePostsynaptic cellDegree of facilitationDirect stimulationImmunohistochemical analysis of the relation between 5‐hydroxytryptamine‐ and neuropeptide‐immunoreactive elements in the spinal cord of an amphibian (Xenopus laevis)
Pieribone V, Brodin L, Hökfelt T. Immunohistochemical analysis of the relation between 5‐hydroxytryptamine‐ and neuropeptide‐immunoreactive elements in the spinal cord of an amphibian (Xenopus laevis). The Journal Of Comparative Neurology 1994, 341: 492-506. PMID: 7515401, DOI: 10.1002/cne.903410406.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptidePeptide-immunoreactive fibersCorticotropin-releasing factorSubstance PSpinal cordImmunoreactive fibersXenopus laevis spinal cordCCK-immunoreactive fibersGene-related peptideCRF-immunoreactive fibersLabeling of fibersDouble-labeling techniqueGAL immunoreactivitySpinal transectionPeptide immunoreactivityImmunohistochemical analysisGalaninImmunohistochemical dataRostrocaudal levelsCordIntact animalsSimilar negative resultsImmunoreactive materialImmunofluorescence double-labeling techniqueCholecystokinin
1993
Cellular localization of messenger RNA for beta-1 and beta-2 adrenergic receptors in rat brain: An in situ hybridization study
Nicholas AP, Pieribone VA, Hökfelt T. Cellular localization of messenger RNA for beta-1 and beta-2 adrenergic receptors in rat brain: An in situ hybridization study. Neuroscience 1993, 56: 1023-1039. PMID: 8284033, DOI: 10.1016/0306-4522(93)90148-9.Peer-Reviewed Original ResearchConceptsSpinal cordRat brainCentral nervous system circuitryBeta 1Messenger RNABeta-receptor subtypesThalamic intralaminar nucleiAnterior olfactory nucleusBeta 1 receptorsIntermediate gray matterReticular thalamic nucleusMedullary reticular formationNervous system circuitryReceptor messenger RNABeta 1 messenger RNABeta-2 adrenergic receptorsCentral nervous systemRat beta 1Selective labeling patternsDeep cerebellar nucleiUnfixed rat brainOlfactory nucleusTrapezoid nucleusCerebral cortexSitu hybridization studiesCGRP-like immunoreactivity in A11 dopamine neurons projecting to the spinal cord and a note on CGRP-CCK cross-reactivity
Orazzo C, Pieribone V, Ceccatelli S, Terenius L, Hökfelt T. CGRP-like immunoreactivity in A11 dopamine neurons projecting to the spinal cord and a note on CGRP-CCK cross-reactivity. Brain Research 1993, 600: 39-48. PMID: 8422589, DOI: 10.1016/0006-8993(93)90399-8.Peer-Reviewed Original ResearchConceptsCGRP antiserumSpinal cordRat brainCalcitonin gene-related peptideDopamine cell groupsCGRP-like immunoreactivityGene-related peptideIndirect immunofluorescence techniqueLike immunoreactivityDopamine neuronsBrain areasDouble-labeling procedureImmunofluorescence techniqueCell groupsCholecystokininCatecholamine groupsCordImmunohistochemistryImmunoreactivityNeuronsRadioimmunoassayBrainPresent studyTerminal portionAntiserum
1992
Serotonin-, substance P- and glutamate/aspartate-like immunoreactivities in medullo-spinal pathways of rat and primate
Nicholas AP, Pieribone VA, Arvidsson U, Hökfelt T. Serotonin-, substance P- and glutamate/aspartate-like immunoreactivities in medullo-spinal pathways of rat and primate. Neuroscience 1992, 48: 545-559. PMID: 1376453, DOI: 10.1016/0306-4522(92)90401-m.Peer-Reviewed Original ResearchConceptsAspartate-like immunoreactivityExcitatory amino acidsSubstance PColchicine-treated ratsSpinal cordLarger alpha motor neuronsB3 cell groupSubstance P neuronsAlpha motor neuronsGlutamate-like immunoreactivityTripeptide thyrotropin-releasing hormoneDistribution of serotoninThyrotropin-releasing hormoneUndecapeptide substance PImmunohistofluorescence techniqueMedullary neuronsImmunoreactive neuronsRaphe neuronsVentral hornRetrograde tracingSerotonergic neuronsMedulla oblongataSpinal projectionsLarge boutonsAutonomic cellsCalcitonin Gene‐Related Peptide in the Brain, Spinal Cord, and Some Peripheral Systemsa
HÖKFELT T, ARVIDSSON U, CECCATELLI S, CORTÉS R, CULLHEIM S, DAGERLIND Å, JOHNSON H, ORAZZO C, PIEHL F, PIERIBONE V, SCHALLING M, TERENIUS L, ULFHAKE B, VERGE V, VILLAR M, WIESENFELD‐HALLIN Z, XU X, XU Z. Calcitonin Gene‐Related Peptide in the Brain, Spinal Cord, and Some Peripheral Systemsa. Annals Of The New York Academy Of Sciences 1992, 657: 119-134. PMID: 1637079, DOI: 10.1111/j.1749-6632.1992.tb22762.x.Peer-Reviewed Original Research
1986
The Brain Nucleus Locus Coeruleus: Restricted Afferent Control of a Broad Efferent Network
Aston-Jones G, Ennis M, Pieribone V, Nickell W, Shipley M. The Brain Nucleus Locus Coeruleus: Restricted Afferent Control of a Broad Efferent Network. Science 1986, 234: 734-737. PMID: 3775363, DOI: 10.1126/science.3775363.Peer-Reviewed Original ResearchConceptsLocus coeruleusWheat germ agglutinin conjugated horseradish peroxidaseParaventricular hypothalamic nucleusNucleus locus coeruleusConjugated horseradish peroxidaseMinor afferentsAfferent neuronsRetrograde labelingHypothalamic nucleiIntermediate grayElectrophysiologic experimentsFocal injectionsPrepositus hypoglossiRostral medullaDorsal capAfferent controlBrain nucleiCoeruleusEfferent networkBrain regionsAnatomic organizationAbsence of inputParagigantocellularisAfferentsHypoglossi