Dehydroepiandrosterone mediates associations between trauma‐related symptoms and anterior pituitary volume in children and adolescents
Picci G, Casagrande C, Ott L, Petro N, Christopher‐Hayes N, Johnson H, Willett M, Okelberry H, Wang Y, Stephen J, Calhoun V, Wilson T. Dehydroepiandrosterone mediates associations between trauma‐related symptoms and anterior pituitary volume in children and adolescents. Human Brain Mapping 2023, 44: 6388-6398. PMID: 37853842, PMCID: PMC10681633, DOI: 10.1002/hbm.26516.Peer-Reviewed Original ResearchConceptsTrauma-related symptomsAnxiety symptomsPituitary volumeAnterior pituitary volumeConsistent with adult findingsHigh-resolution T1-weighted MRI scansPG volumeEarly life stressLevels of dehydroepiandrosteroneT1-weighted MRI scansDehydroepiandrosterone levelsPituitary glandResponse to stressComorbid anxietyNeurobiological sequelaeSubclinical anxietyLife stressAnxiety/depression symptomsElevated anxietyAdult findingsAssociated with disruptionDevelopmental sampleHealthy youthTrained ratersPubertal windowAddressing Global Environmental Challenges to Mental Health Using Population Neuroscience
Schumann G, Andreassen O, Banaschewski T, Calhoun V, Clinton N, Desrivieres S, Brandlistuen R, Feng J, Hese S, Hitchen E, Hoffmann P, Jia T, Jirsa V, Marquand A, Nees F, Nöthen M, Novarino G, Polemiti E, Ralser M, Rapp M, Schepanski K, Schikowski T, Slater M, Sommer P, Stahl B, Thompson P, Twardziok S, van der Meer D, Walter H, Westlye L, Heinz A, Lett T, Vaidya N, Serin E, Neidhart M, Jentsch M, Eils R, Taron U, Schütz T, Banks J, Meyer-Lindenberg A, Tost H, Holz N, Schwarz E, Stringaris A, Christmann N, Jansone K, Siehl S, Ask H, Fernández-Cabello S, Kjelkenes R, Tschorn M, Böttger S, Bernas A, Marr L, Feixas Viapiana G, Eiroa-Orosa F, Gallego J, Pastor A, Forstner A, Claus I, Miller A, Heilmann-Heimbach S, Boye M, Wilbertz J, Schmitt K, Petkoski S, Pitel S, Otten L, Athanasiadis A, Pearmund C, Spanlang B, Alvarez E, Sanchez M, Giner A, Renner P, Gong Y, Dai Y, Xia Y, Chang X, Liu J, Young A, Ogoh G. Addressing Global Environmental Challenges to Mental Health Using Population Neuroscience. JAMA Psychiatry 2023, 80: 1066-1074. PMID: 37610741, DOI: 10.1001/jamapsychiatry.2023.2996.Peer-Reviewed Original ResearchConceptsMental illnessMechanisms of mental illnessSymptoms of depressionEvidence-based interventionsBrain mechanismsPopulation neuroscienceSocioeconomic inequalitiesEnvironmental adversityMental healthSubstance misuseBrain healthPsychosocial effectsDigital healthCohort dataDeep phenotyping dataObjective biomarkersHealthIllnessBrainDevelopment of objective biomarkersImprove outcomesPopulation levelCOVID-19 pandemicPollution measurementsResearch strategy