2024
Neurodevelopmental subtypes of functional brain organization in the ABCD study using a rigorous analytic framework
DeRosa J, Friedman N, Calhoun V, Banich M. Neurodevelopmental subtypes of functional brain organization in the ABCD study using a rigorous analytic framework. NeuroImage 2024, 299: 120827. PMID: 39245397, DOI: 10.1016/j.neuroimage.2024.120827.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAdolescent Brain Cognitive DevelopmentIndividual’s resting-state functional connectivityAdolescent Brain Cognitive Development StudyFunctional brain organizationMental health profilesMental health characteristicsRsFC dataBrain organizationFunctional connectivityDevelopmental trajectoriesChildren aged 9Emotional functioningCognitive developmentLate childhoodAged 9SubtypesAdolescentsHealth characteristicsHealth profileChildhoodJoint multi-site domain adaptation and multi-modality feature selection for the diagnosis of psychiatric disorders
Ji Y, Silva R, Adali T, Wen X, Zhu Q, Jiang R, Zhang D, Qi S, Calhoun V. Joint multi-site domain adaptation and multi-modality feature selection for the diagnosis of psychiatric disorders. NeuroImage Clinical 2024, 43: 103663. PMID: 39226701, DOI: 10.1016/j.nicl.2024.103663.Peer-Reviewed Original ResearchAssociations of alcohol and tobacco use with psychotic, depressive and developmental disorders revealed via multimodal neuroimaging
Qiu L, Liang C, Kochunov P, Hutchison K, Sui J, Jiang R, Zhi D, Vergara V, Yang X, Zhang D, Fu Z, Bustillo J, Qi S, Calhoun V. Associations of alcohol and tobacco use with psychotic, depressive and developmental disorders revealed via multimodal neuroimaging. Translational Psychiatry 2024, 14: 326. PMID: 39112461, PMCID: PMC11306356, DOI: 10.1038/s41398-024-03035-2.Peer-Reviewed Original ResearchConceptsFronto-limbic networkSalience networkAssociated with cognitionFronto-basal gangliaDevelopmental disordersBrain networksLimbic systemAlcohol useAssociated with alcohol useMultimodal brain networksTobacco useAssociation of alcoholPsychiatric disordersMultimodal neuroimagingDMNBrain featuresCognitionAlcohol/tobacco useDisordersAssociated with tobacco useDepressionSymptomsFunctional abnormalitiesAlcoholBrainEffects of endogenous testosterone on oscillatory activity during verbal working memory in youth
Killanin A, Ward T, Embury C, Calhoun V, Wang Y, Stephen J, Picci G, Heinrichs‐Graham E, Wilson T. Effects of endogenous testosterone on oscillatory activity during verbal working memory in youth. Human Brain Mapping 2024, 45: e26774. PMID: 38949599, PMCID: PMC11215982, DOI: 10.1002/hbm.26774.Peer-Reviewed Original ResearchConceptsVerbal working memoryVerbal working memory processingWorking memory processesWorking memoryEffects of chronological ageEndogenous testosterone levelsMemory processesOscillatory activitySternberg verbal working memory taskEffects of testosteroneLeft-lateralized language networkVerbal working memory taskAlpha oscillationsSalivary testosterone samplesWorking memory encodingWorking memory taskLeft temporal cortexRight cerebellar cortexNeural oscillatory activitySignificant oscillatory responsesNeural oscillatory dynamicsHuman brain structureCerebellar cortexYouth aged 6Chronological ageMRI morphometry of the anterior and posterior cerebellar vermis and its relationship to sensorimotor and cognitive functions in children
Hodgdon E, Anderson R, Al Azzawi H, Wilson T, Calhoun V, Wang Y, Solis I, Greve D, Stephen J, Ciesielski K. MRI morphometry of the anterior and posterior cerebellar vermis and its relationship to sensorimotor and cognitive functions in children. Developmental Cognitive Neuroscience 2024, 67: 101385. PMID: 38713999, PMCID: PMC11096723, DOI: 10.1016/j.dcn.2024.101385.Peer-Reviewed Original ResearchConceptsLobules I-VCognitive functionCerebellar vermis volumePosterior brain structuresCerebellar vermisVI-VIIAnterior cerebellar vermisLobules VI-VIIWASI-IIEmotional processingVermis volumeNeuropsychological scoresPosterior cerebellar vermisBrain structuresDevelopmental trajectoriesMRI morphometryCerebellar anatomyPosterior vermisSensorimotorDevelopmental studiesHuman cerebellumHealthy adultsAdult volumeVermisHigh-resolution MRISearching Reproducible Brain Features using NeuroMark: Templates for Different Age Populations and Imaging Modalities
Fu Z, Batta I, Wu L, Abrol A, Agcaoglu O, Salman M, Du Y, Iraji A, Shultz S, Sui J, Calhoun V. Searching Reproducible Brain Features using NeuroMark: Templates for Different Age Populations and Imaging Modalities. NeuroImage 2024, 292: 120617. PMID: 38636639, PMCID: PMC11416721, DOI: 10.1016/j.neuroimage.2024.120617.Peer-Reviewed Original ResearchConceptsFunctional MRIStructural MRIResting-state scanSpatial similarity analysisMental health researchBrain markersDiffusion MRIAge differencesBrain featuresNeuromarkersBrain disordersYoung adult cohortBrain developmentWell-replicatedHuman brainBrainDiffusion MRI dataData-driven analysisDisordersSimilarity analysisAge cohortsGeneralizabilityPopulation-based researchAdult cohortAge-specific adaptationReconfiguration of Structural and Functional Connectivity Coupling in Patient Subgroups With Adolescent Depression
Xu M, Li X, Teng T, Huang Y, Liu M, Long Y, Lv F, Zhi D, Li X, Feng A, Yu S, Calhoun V, Zhou X, Sui J. Reconfiguration of Structural and Functional Connectivity Coupling in Patient Subgroups With Adolescent Depression. JAMA Network Open 2024, 7: e241933. PMID: 38470418, PMCID: PMC10933730, DOI: 10.1001/jamanetworkopen.2024.1933.Peer-Reviewed Original ResearchConceptsAdolescent major depressive disorderMajor depressive disorderSC-FC couplingIncreased SC-FC couplingSC-FCMode networkSuicide attemptsFirst-episode major depressive disorderVisual networkMDD subgroupsNonsuicidal self-injurious behaviorRates of self-injuryHealthy controlsResting-state functional MRI dataMagnetic resonance imagingCross-sectional studySelf-injurious behaviorOutpatient psychiatry clinicFunctional MRI dataMajor life eventsFirst Affiliated Hospital of Chongqing Medical UniversityDepressive disorderNeurobiological mechanismsChildhood traumaSelf-injury
2023
Age-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains
Anderson J, Calhoun V, Pearlson G, Hawkins K, Stevens M. Age-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains. Developmental Cognitive Neuroscience 2023, 64: 101318. PMID: 37875033, PMCID: PMC10618425, DOI: 10.1016/j.dcn.2023.101318.Peer-Reviewed Original ResearchConceptsExecutive function domainsResponse inhibitionWhite matter microstructureLower response inhibitionStructure-cognition relationshipsEF abilitiesBehavioral performanceCognitive imbalanceNeurocognitive testsFunction domainTest performanceYoung adulthoodFractional anisotropyBrain changesAge 12Young adultsSS performanceWhite matter FA valuesGreater relianceWhite matter changesWhite matter microstructural differencesSubjects ages 12White matter skeletonIndependent componentsMultivariate associationsDehydroepiandrosterone mediates associations between trauma‐related symptoms and anterior pituitary volume in children and adolescents
Picci G, Casagrande C, Ott L, Petro N, Christopher‐Hayes N, Johnson H, Willett M, Okelberry H, Wang Y, Stephen J, Calhoun V, Wilson T. Dehydroepiandrosterone mediates associations between trauma‐related symptoms and anterior pituitary volume in children and adolescents. Human Brain Mapping 2023, 44: 6388-6398. PMID: 37853842, PMCID: PMC10681633, DOI: 10.1002/hbm.26516.Peer-Reviewed Original ResearchConceptsTrauma-related symptomsAnxiety symptomsPituitary volumeAnterior pituitary volumeConsistent with adult findingsHigh-resolution T1-weighted MRI scansPG volumeEarly life stressLevels of dehydroepiandrosteroneT1-weighted MRI scansDehydroepiandrosterone levelsPituitary glandResponse to stressComorbid anxietyNeurobiological sequelaeSubclinical anxietyLife stressAnxiety/depression symptomsElevated anxietyAdult findingsAssociated with disruptionDevelopmental sampleHealthy youthTrained ratersPubertal windowDevelopmental changes in endogenous testosterone have sexually‐dimorphic effects on spontaneous cortical dynamics
Picci G, Ott L, Penhale S, Taylor B, Johnson H, Willett M, Okelberry H, Wang Y, Calhoun V, Stephen J, Wilson T. Developmental changes in endogenous testosterone have sexually‐dimorphic effects on spontaneous cortical dynamics. Human Brain Mapping 2023, 44: 6043-6054. PMID: 37811842, PMCID: PMC10619376, DOI: 10.1002/hbm.26496.Peer-Reviewed Original ResearchConceptsCortical activityRobust sex differencesFunctional brain developmentTypically-developing youthSpontaneous cortical activityLowest relative powerCortical dynamicsEndogenous testosteronePrefrontal cortexExecutive functionFrontal cortexPubertal hormonesNeural circuitryResting-stateStructural MRIEffects of testosteroneSex differencesEffects of endogenous testosteroneDevelopmental changesBrain developmentReverse patternBehavioral changesGamma activityDevelopmental windowDevelopmental patternsDevelopmental alterations in the neural oscillatory dynamics underlying attentional reorienting
Picci G, Ott L, Petro N, Casagrande C, Killanin A, Rice D, Coutant A, Arif Y, Embury C, Okelberry H, Johnson H, Springer S, Pulliam H, Wang Y, Calhoun V, Stephen J, Heinrichs-Graham E, Taylor B, Wilson T. Developmental alterations in the neural oscillatory dynamics underlying attentional reorienting. Developmental Cognitive Neuroscience 2023, 63: 101288. PMID: 37567094, PMCID: PMC10432959, DOI: 10.1016/j.dcn.2023.101288.Peer-Reviewed Original ResearchConceptsAllocation of attentionBrain regionsFlexible allocation of attentionNetwork of brain regionsProtracted developmental coursePrefrontal brain regionsBrain-behavior associationsFronto-parietal networkHigher-order visual regionsNetwork of regionsAge-related improvementsTheta oscillatory activitySignificant oscillatory responsesNeural oscillatory dynamicsAttentional reorientingBehavioral performanceDevelopmental improvementCognitive processesDevelopmental courseHealthy youthTheta oscillationsVisual regionsMagnetoencephalography dataFunction of ageFlexible allocationFunctional and Structural Longitudinal Change Patterns in Adolescent Brain
Saha R, Saha D, Fu Z, Silva R, Calhoun V. Functional and Structural Longitudinal Change Patterns in Adolescent Brain. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2023, 00: 1-4. PMID: 38082649, DOI: 10.1109/embc40787.2023.10340079.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingStructural magnetic resonance imagingFunctional network connectivityWhole-brainGray matterBrain functional magnetic resonance imagingMagnetic resonance imagingAdolescent brainFunctional connectivityResonance imagingMultivariate patternsLongitudinal change patternsUnivariate changesAdolescentsLongitudinal changesBrainIncreasing ageFunctional changesComplementary techniquesNetwork connectivityICA-based Individualized Differential Structure Similarity Networks for Predicting Symptom Scores in Adolescents with Major Depressive Disorder
Li X, Xu M, Jiang R, Li X, Calhoun V, Zhou X, Sui J. ICA-based Individualized Differential Structure Similarity Networks for Predicting Symptom Scores in Adolescents with Major Depressive Disorder. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2023, 00: 1-5. PMID: 38082692, DOI: 10.1109/embc40787.2023.10340456.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainConnectomeDepressive Disorder, MajorGray MatterHumansMagnetic Resonance ImagingConceptsMajor depressive disorderGray matter volumeDepressive disorderWhole-brain structural covariance networksConnectome-based predictive modelingAdolescent MDD patientsComplex mood disorderMeasure individual differencesDefault-mode networkStructural brain alterationsStructural covariance networksHamilton Depression ScaleHamilton Anxiety ScaleSpatially constrained ICAMDD patientsMood disordersBrain alterationsMatter volumeIndividual differencesBrain structuresCovariance networksAnxiety ScaleVisual networkDepression ScaleStructure similarity networkDevelopmental differences in functional organization of multispectral networks
Petro N, Picci G, Embury C, Ott L, Penhale S, Rempe M, Johnson H, Willett M, Wang Y, Stephen J, Calhoun V, Doucet G, Wilson T. Developmental differences in functional organization of multispectral networks. Cerebral Cortex 2023, 33: 9175-9185. PMID: 37279931, PMCID: PMC10505424, DOI: 10.1093/cercor/bhad193.Peer-Reviewed Original ResearchConceptsSpontaneous cortical activityPhase coherenceImaginary partFunctional magnetic resonance imaging measuresConsistent with previous workFunctional brain organizationLimbic cortical regionsFunctional organizationBrain connectivityFunction of increasing ageEyes-closed restGamma bandSpectral specificityConnectivity matrixBrain regionsCanonical deltaBrain organizationBrain activityFunctional connectivityDevelopmental differencesBandCortical regionsCanonical networksCortical activityMagnetic resonance imaging measuresTestosterone levels mediate the dynamics of motor oscillatory coding and behavior in developing youth
Killanin A, Taylor B, Embury C, Picci G, Wang Y, Calhoun V, Stephen J, Heinrichs-Graham E, Wilson T. Testosterone levels mediate the dynamics of motor oscillatory coding and behavior in developing youth. Developmental Cognitive Neuroscience 2023, 61: 101257. PMID: 37236034, PMCID: PMC10232658, DOI: 10.1016/j.dcn.2023.101257.Peer-Reviewed Original ResearchConceptsMotor performanceEffects of ageSalivary testosterone samplesMotor sequence taskMultiple mediation modelMovement-related beta activityBeta oscillatory dynamicsMeasures of motor performanceYouth aged 9Complex motor performanceLeft primary motor cortexPubertal transition periodBeta activitySequencing taskTestosterone samplesMediation modelMotor planningMotor regionsTask behaviorPrimary motor cortexDevelopmental changesBehavior indexYoung adulthoodTestosterone levelsAged 9A systematic review of neuroimaging epigenetic research: calling for an increased focus on development
Walton E, Baltramonaityte V, Calhoun V, Heijmans B, Thompson P, Cecil C. A systematic review of neuroimaging epigenetic research: calling for an increased focus on development. Molecular Psychiatry 2023, 28: 2839-2847. PMID: 37185958, PMCID: PMC10615743, DOI: 10.1038/s41380-023-02067-2.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainChildDNA MethylationEpigenesis, GeneticHumansNeuroimagingProspective StudiesConceptsFunctional neuroimaging measuresBrain-based disordersBrain imaging measuresBrain alterationsNeuroimaging measuresBrain outcomesInvestigate environmental influencesBehavioral outcomesDevelopmental periodEnvironmental influencesSample characteristicsDNA methylationSystematically review evidenceBrainTime of lifeDisordersMeasurement of DNA methylationContext of healthImaging measurementsCandidate-gene approachEpigenetic mechanismsEpigenetic researchMeta-analysisDNA methylation markersYears of age