2024
Explainable Multimodal Graph Isomorphism Network for Interpreting Sex Differences in Adolescent Neurodevelopment
Patel B, Orlichenko A, Patel A, Qu G, Wilson T, Stephen J, Calhoun V, Wang Y. Explainable Multimodal Graph Isomorphism Network for Interpreting Sex Differences in Adolescent Neurodevelopment. Applied Sciences 2024, 14: 4144. DOI: 10.3390/app14104144.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingBlood oxygen level-dependentGraph isomorphism networkGraph neural networksBrain networksFunctional magnetic resonance imaging paradigmFunctional magnetic resonance imaging blood oxygen level-dependentSex differencesClassification accuracyExploration of sex differencesInterpreting sex differencesOxygen level-dependentState-of-the-art algorithmsAdolescent neurodevelopmentState-of-the-artNeuropsychiatric conditionsFunctional connectivityTask-related dataDeep learning modelsLevel-dependentMouth movementsFMRI datasetsFunctional networksGraph structureAdolescentsCorrelates of axonal content in healthy adult span: Age, sex, myelin, and metabolic health
Burzynska A, Anderson C, Arciniegas D, Calhoun V, Choi I, Mendez Colmenares A, Kramer A, Li K, Lee J, Lee P, Thomas M. Correlates of axonal content in healthy adult span: Age, sex, myelin, and metabolic health. Cerebral Circulation - Cognition And Behavior 2024, 6: 100203. PMID: 38292016, PMCID: PMC10827486, DOI: 10.1016/j.cccb.2024.100203.Peer-Reviewed Original ResearchNeurologically healthy adultsHealthy adultsLow metabolic riskAdult spanNeural targetsSex differencesIntracranial volumeModifiable health risk factorsMetabolic riskMyelin contentHealth risk factorsAlzheimer's diseaseWhite matterNeurite orientation dispersionPeripheral metabolismMRI approachModifiable factorsAdiposity scoreAdultsMetabolic healthRisk factorsMetabolic syndromeVulnerabilityNeurologyWMSexual dimorphism in cortical theta rhythms relates to elevated internalizing symptoms during adolescence
Petro N, Picci G, Ott L, Rempe M, Embury C, Penhale S, Wang Y, Stephen J, Calhoun V, Taylor B, Wilson T. Sexual dimorphism in cortical theta rhythms relates to elevated internalizing symptoms during adolescence. Imaging Neuroscience 2024, 2: 1-13. DOI: 10.1162/imag_a_00062.Peer-Reviewed Original ResearchSpontaneous neural activityInternalizing symptomsNeural activityPsychiatric disordersEmergence of psychiatric disordersTheta activityEmergence of psychiatric symptomsAbstract Psychiatric disordersElevated internalizing symptomsStructural brain differencesTypically-developing youthSpontaneous theta activityEyes-closed restTheta frequency bandNegative ruminationCingulate cortexTemporoparietal junctionBrain differencesExternalizing symptomsPsychiatric symptomsAssociation cortexCortical regionsSex differencesCortical activityAssociation regions
2023
Developmental changes in endogenous testosterone have sexually‐dimorphic effects on spontaneous cortical dynamics
Picci G, Ott L, Penhale S, Taylor B, Johnson H, Willett M, Okelberry H, Wang Y, Calhoun V, Stephen J, Wilson T. Developmental changes in endogenous testosterone have sexually‐dimorphic effects on spontaneous cortical dynamics. Human Brain Mapping 2023, 44: 6043-6054. PMID: 37811842, PMCID: PMC10619376, DOI: 10.1002/hbm.26496.Peer-Reviewed Original ResearchConceptsCortical activityRobust sex differencesFunctional brain developmentTypically-developing youthSpontaneous cortical activityLowest relative powerCortical dynamicsEndogenous testosteronePrefrontal cortexExecutive functionFrontal cortexPubertal hormonesNeural circuitryResting-stateStructural MRIEffects of testosteroneSex differencesEffects of endogenous testosteroneDevelopmental changesBrain developmentReverse patternBehavioral changesGamma activityDevelopmental windowDevelopmental patterns