2024
Frequency modulation increases the specificity of time-resolved connectivity: A resting-state fMRI study
Faghiri A, Yang K, Faria A, Ishizuka K, Sawa A, Adali T, Calhoun V. Frequency modulation increases the specificity of time-resolved connectivity: A resting-state fMRI study. Network Neuroscience 2024, 8: 734-761. PMID: 39355435, PMCID: PMC11349031, DOI: 10.1162/netn_a_00372.Peer-Reviewed Original ResearchSliding window Pearson correlationTime-resolved networksSingle sideband modulationTime-resolved connectivityResting-state fMRI studiesSideband modulationFunctional magnetic resonance imagingFunctional network connectivityResting-state functional magnetic resonance imagingActivity time seriesTypical controlsFrequency modulationLow-frequency informationStateEpisode of psychosisNetwork connectivityHuman brainSub-corticalSuperior performanceFMRI studyCortical regions4D dynamic spatial brain networks at rest linked to cognition show atypical variability and coupling in schizophrenia
Pusuluri K, Fu Z, Miller R, Pearlson G, Kochunov P, Van Erp T, Iraji A, Calhoun V. 4D dynamic spatial brain networks at rest linked to cognition show atypical variability and coupling in schizophrenia. Human Brain Mapping 2024, 45: e26773. PMID: 39045900, PMCID: PMC11267451, DOI: 10.1002/hbm.26773.Peer-Reviewed Original ResearchConceptsBrain networksFunctional magnetic resonance imagingAssociated with cognitive performanceDynamics of functional brain networksAssociated with cognitionFunctional brain networksVoxel-wise changesVolumetric couplingDynamical variablesCognitive performanceTypical controlsSchizophreniaCognitive impairmentNetwork pairsMagnetic resonance imagingPair of networksCognitionAtypical variabilityResonance imagingCouplingNetwork connectivityNetwork growthImpairmentBrainStatic networksDynamic Functional Connectivity Correlates of Trait Mindfulness in Early Adolescence
Treves I, Marusak H, Decker A, Kucyi A, Hubbard N, Bauer C, Leonard J, Grotzinger H, Giebler M, Torres Y, Imhof A, Romeo R, Calhoun V, Gabrieli J. Dynamic Functional Connectivity Correlates of Trait Mindfulness in Early Adolescence. Biological Psychiatry Global Open Science 2024, 4: 100367. PMID: 39286525, PMCID: PMC11402920, DOI: 10.1016/j.bpsgos.2024.100367.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingTrait mindfulnessFunctional connectivity analysisDynamic functional connectivity analysisBrain statesConnectivity analysisSelf-reported trait mindfulnessResting-state fMRI scansHigher trait mindfulnessPresent-moment experienceFunctional connectivity correlatesDynamic brain statesStatic functional connectivityState-of-mindTest-retest reliabilityAdolescent anxietyFMRI scanningNeural basisPsychiatric disordersDepressive symptomsNeural mechanismsLower anxietyFunctional connectivityEarly adolescenceConnectivity correlationsA new transfer entropy method for measuring directed connectivity from complex-valued fMRI data
Li W, Lin Q, Zhang C, Han Y, Calhoun V. A new transfer entropy method for measuring directed connectivity from complex-valued fMRI data. Frontiers In Neuroscience 2024, 18: 1423014. PMID: 39050665, PMCID: PMC11266018, DOI: 10.3389/fnins.2024.1423014.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingFMRI dataBrain regionsAnatomical Automatic LabelingTransfer entropyFunctional magnetic resonance imaging dataConnectivity of brain regionsFrontal-parietal regionsConsistent with previous findingsSignificant group differencesRight frontal-parietal regionPartial transfer entropyPredicting mental disordersMental disordersParietal regionsGroup differencesMagnitude effectExperimental fMRI dataDirectional connectivityComplex-valued fMRI dataSchizophreniaMagnetic resonance imagingComplex-valued approachEntropyMagnitude dataAssociation between the oral microbiome and brain resting state connectivity in schizophrenia
Lin D, Fu Z, Liu J, Perrone-Bizzozero N, Hutchison K, Bustillo J, Du Y, Pearlson G, Calhoun V. Association between the oral microbiome and brain resting state connectivity in schizophrenia. Schizophrenia Research 2024, 270: 392-402. PMID: 38986386, DOI: 10.1016/j.schres.2024.06.045.Peer-Reviewed Original ResearchOral microbiomeMicrobial speciesArea under curveResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingMicrobial 16S rRNA sequencingBrain circuit dysfunctionHealthy controlsBrain functional connectivity alterationsFunctional connectivity alterationsFunctional neuroimaging techniquesHypothalamic-pituitary-adrenal axisBrain functional connectivityFunctional network connectivityBrain functional activityBrain functional network connectivityHealthy control subjectsNeurotransmitter signaling pathwaysBeta diversityMicrobiome communitiesOral microbiome dysbiosisRRNA sequencingCircuit dysfunctionConnectivity alterationsSchizophreniaMulti-modal deep learning from imaging genomic data for schizophrenia classification
Kanyal A, Mazumder B, Calhoun V, Preda A, Turner J, Ford J, Ye D. Multi-modal deep learning from imaging genomic data for schizophrenia classification. Frontiers In Psychiatry 2024, 15: 1384842. PMID: 39006822, PMCID: PMC11239396, DOI: 10.3389/fpsyt.2024.1384842.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsGenomic dataGenetic markersGenomic markersBrains of individualsNucleotide polymorphismsEtiology of SZFunctional magnetic resonance imagingStructural magnetic resonance imagingMorphological featuresLayerwise relevance propagationHereditary aspectsHealthy controlsMarkersA survey of brain functional network extraction methods using fMRI data
Du Y, Fang S, He X, Calhoun V. A survey of brain functional network extraction methods using fMRI data. Trends In Neurosciences 2024, 47: 608-621. PMID: 38906797, DOI: 10.1016/j.tins.2024.05.011.Peer-Reviewed Original ResearchLearning Spatiotemporal Brain Dynamics in Adolescents via Multimodal MEG and fMRI Data Fusion Using Joint Tensor/Matrix Decomposition
Belyaeva I, Gabrielson B, Wang Y, Wilson T, Calhoun V, Stephen J, Adali T. Learning Spatiotemporal Brain Dynamics in Adolescents via Multimodal MEG and fMRI Data Fusion Using Joint Tensor/Matrix Decomposition. IEEE Transactions On Biomedical Engineering 2024, 71: 2189-2200. PMID: 38345949, PMCID: PMC11240882, DOI: 10.1109/tbme.2024.3364704.Peer-Reviewed Original ResearchSpatiotemporal brain dynamicsBrain dynamicsFunctional magnetic resonance imagingComplex spatiotemporal dynamicsStudy brain functionSpatial resolutionMillisecond scaleBrain functionTemporal resolutionBrain patternsHigh-level cognitive functionsBrain response patternsDynamicsSpatiotemporal dynamicsSensory processing pathwaysMagnetoencephalographyLow-performing subjectsResolutionA Trifecta of Deep Learning Models: Assessing Brain Health by Integrating Assessment and Neuroimaging Data
Ajith M, M. Aycock D, B. Tone E, Liu J, B. Misiura M, Ellis R, M. Plis S, Z. King T, M. Dotson V, Calhoun V. A Trifecta of Deep Learning Models: Assessing Brain Health by Integrating Assessment and Neuroimaging Data. Aperture Neuro 2024, 4 DOI: 10.52294/001c.118576.Peer-Reviewed Original ResearchStatic functional network connectivityBrain health indexBrain healthResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingPsychological assessment measuresAssessment dataFunctional network connectivityMental health disordersBrain systemsEvaluating brain healthNeuroimaging dataRs-fMRINeural patternsPhysical well-beingCognitive declineAssessment measuresHealth disordersVariational autoencoderNeuroimagingHealthy brainBrainMagnetic resonance imagingTesting phaseWell-beingThe dynamics of dynamic time warping in fMRI data: A method to capture inter-network stretching and shrinking via warp elasticity
Wiafe S, Faghiri A, Fu Z, Miller R, Preda A, Calhoun V. The dynamics of dynamic time warping in fMRI data: A method to capture inter-network stretching and shrinking via warp elasticity. Imaging Neuroscience 2024, 2: 1-23. DOI: 10.1162/imag_a_00187.Peer-Reviewed Original ResearchDynamic time warpingDynamics of brain networksBrain networksBrain network interactionsFunctional magnetic resonance imagingFunctional connectivity measuresComplexity of brain functionDiverse timescalesTime warpingBrain dynamicsVisual cortexFunctional magnetic resonance imaging dataTimescalesFunctional connectivityBrain connectivityCoupled stretchingCouplingDynamic time warping methodBrain regionsTransient couplingConnectivity measuresFunctional connectivity metricsNeuroimaging researchCluster centroidsIntricate dynamicsA confounder controlled machine learning approach: Group analysis and classification of schizophrenia and Alzheimer’s disease using resting-state functional network connectivity
Hassanzadeh R, Abrol A, Pearlson G, Turner J, Calhoun V. A confounder controlled machine learning approach: Group analysis and classification of schizophrenia and Alzheimer’s disease using resting-state functional network connectivity. PLOS ONE 2024, 19: e0293053. PMID: 38768123, PMCID: PMC11104643, DOI: 10.1371/journal.pone.0293053.Peer-Reviewed Original ResearchConceptsResting-state functional network connectivityFunctional network connectivityResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingAlzheimer's diseaseClassification of schizophreniaNetwork pairsPatients to healthy controlsSchizophrenia patientsNeurobiological mechanismsSZ patientsSubcortical networksCerebellum networkSchizophreniaRs-fMRIDisorder developmentMotor networkCompare patient groupsSubcortical domainSZ disorderHealthy controlsMagnetic resonance imagingDisordersNetwork connectivityFunctional abnormalitiesExplainable Multimodal Graph Isomorphism Network for Interpreting Sex Differences in Adolescent Neurodevelopment
Patel B, Orlichenko A, Patel A, Qu G, Wilson T, Stephen J, Calhoun V, Wang Y. Explainable Multimodal Graph Isomorphism Network for Interpreting Sex Differences in Adolescent Neurodevelopment. Applied Sciences 2024, 14: 4144. DOI: 10.3390/app14104144.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingBlood oxygen level-dependentGraph isomorphism networkGraph neural networksBrain networksFunctional magnetic resonance imaging paradigmFunctional magnetic resonance imaging blood oxygen level-dependentSex differencesClassification accuracyExploration of sex differencesInterpreting sex differencesOxygen level-dependentState-of-the-art algorithmsAdolescent neurodevelopmentState-of-the-artNeuropsychiatric conditionsFunctional connectivityTask-related dataDeep learning modelsLevel-dependentMouth movementsFMRI datasetsFunctional networksGraph structureAdolescentsCross‐cohort replicable resting‐state functional connectivity in predicting symptoms and cognition of schizophrenia
Zhao C, Jiang R, Bustillo J, Kochunov P, Turner J, Liang C, Fu Z, Zhang D, Qi S, Calhoun V. Cross‐cohort replicable resting‐state functional connectivity in predicting symptoms and cognition of schizophrenia. Human Brain Mapping 2024, 45: e26694. PMID: 38727014, PMCID: PMC11083889, DOI: 10.1002/hbm.26694.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingNegative symptomsFunctional connectivityCognitive impairmentPrediction of negative symptomsResting-state functional connectivityAssociated with reduced cognitive functionDebilitating mental illnessHealthy controlsPredicting functional connectivityEarly adulthood onsetPositive symptomsNeural underpinningsSchizophreniaCognitive functionSensorimotor networkPredicting symptomsMental illnessConnectivity patternsClinical interventionsMagnetic resonance imagingAdulthood onsetSymptomsImpairmentResonance imagingAnalysis of High-Order Brain Networks Resolved in Time and Frequency Using CP Decomposition
Faghiri A, Iraji A, Adali T, Calhoun V. Analysis of High-Order Brain Networks Resolved in Time and Frequency Using CP Decomposition. 2024, 00: 13346-13350. DOI: 10.1109/icassp48485.2024.10446864.Peer-Reviewed Original ResearchSubgroup Identification Through Multiplex Community Structure Within Functional Connectivity Networks
Yang H, Ortiz-Bouza M, Vu T, Laport F, Calhoun V, Aviyente S, Adali T. Subgroup Identification Through Multiplex Community Structure Within Functional Connectivity Networks. 2024, 00: 2141-2145. DOI: 10.1109/icassp48485.2024.10446076.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingFunctional networksResting-state fMRI dataMultiplex networksMulti-subject functional magnetic resonance imagingNature of psychiatric disordersFunctional connectivity networksDiagnostic heterogeneityPsychotic patientsIndividual functional networksPsychiatric disordersCommunity detectionGroup differencesFMRI dataData-driven methodMultiple networksConnectivity networksMagnetic resonance imagingIdentified subgroupsNetworkSubgroup identificationResonance imagingSubject correlationSubgroup structureDistribution of Connectivity Strengths Across Functional Regions has Higher Entropy in Schizophrenia Patients than in Controls
Maksymchuk N, Miller R, Calhoun V. Distribution of Connectivity Strengths Across Functional Regions has Higher Entropy in Schizophrenia Patients than in Controls. 2024, 00: 37-40. DOI: 10.1109/ssiai59505.2024.10508663.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingGroup independent component analysisSchizophrenia patientsCognitive controlResting-state functional magnetic resonance imagingIntrinsic connectivity networksHealthy controlsGender-matched healthy controlsSZ patientsNeuropsychiatric disordersBrain areasBrain networksSchizophreniaDisrupted integrityBrain domainsConnection strengthIndependent component analysisConnectivity networksMagnetic resonance imagingSomatomotorDistribution of connection strengthsResonance imagingCross-sectional dataPatientsDiagnostic testsSMART (Splitting-Merging Assisted Reliable) Independent Component Analysis for Extracting Accurate Brain Functional Networks
He X, Calhoun V, Du Y. SMART (Splitting-Merging Assisted Reliable) Independent Component Analysis for Extracting Accurate Brain Functional Networks. Neuroscience Bulletin 2024, 40: 905-920. PMID: 38491231, DOI: 10.1007/s12264-024-01184-4.Peer-Reviewed Original ResearchConceptsIndependent component analysisFunctional magnetic resonance imagingClustering independent componentsFunctional networksIndependent component analysis methodMulti-subject fMRI dataIndependent componentsBrain functional networksFMRI dataSubject-specific functional networksFunctional magnetic resonance imaging dataOptimal model orderSmartComponent analysisA whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry
Jensen K, Calhoun V, Fu Z, Yang K, Faria A, Ishizuka K, Sawa A, Andrés-Camazón P, Coffman B, Seebold D, Turner J, Salisbury D, Iraji A. A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry. NeuroImage Clinical 2024, 41: 103584. PMID: 38422833, PMCID: PMC10944191, DOI: 10.1016/j.nicl.2024.103584.Peer-Reviewed Original ResearchConceptsFunctional network connectivityFirst-episodeEarly psychosisAberrant functional network connectivityResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingCorrelates of psychosisResting-state fMRI analysisWhole-brain approachPsychiatric disordersPsychiatric illnessSubcortical regionsCerebellar regionsFMRI analysisPsychosisControl participantsCognitive functionRs-fMRICerebellar connectivityMulti-site datasetFunctional circuitryMagnetic resonance imagingCircuitryResonance imagingProminent pattern
2023
Pairing explainable deep learning classification with clustering to uncover effects of schizophrenia upon whole brain functional network connectivity dynamics
Ellis C, Miller R, Calhoun V. Pairing explainable deep learning classification with clustering to uncover effects of schizophrenia upon whole brain functional network connectivity dynamics. Neuroimage Reports 2023, 3: 100186. DOI: 10.1016/j.ynirp.2023.100186.Peer-Reviewed Original ResearchEffect of schizophreniaDynamic functional network connectivityBrain network dynamicsNeuropsychiatric disordersBrain activityFunctional magnetic resonance imagingInteractions of brain regionsFunctional network connectivityNetwork dynamicsBrain regionsSchizophreniaClustering algorithmEffect of SZHealthy controlsLearning classificationBrainMagnetic resonance imagingDeep learning modelsDeep learning classificationDisordersNetwork interactionsMachine learning classificationResonance imagingClustersNovel measures6 Graph Analysis of Resting State Functional Brain Networks and Associations with Cognitive Outcomes in Survivors on Pediatric Brain Tumor
Semmel E, Calhoun V, Hillary F, Morris R, King T. 6 Graph Analysis of Resting State Functional Brain Networks and Associations with Cognitive Outcomes in Survivors on Pediatric Brain Tumor. Journal Of The International Neuropsychological Society 2023, 29: 316-317. DOI: 10.1017/s135561772300437x.Peer-Reviewed Original ResearchSurvivors of pediatric brain tumorsFunctional brain networksWorking memoryBrain networksCognitive outcomesProcessing speedLong-term neuropsychological deficitsResting state functional magnetic resonance imagingFunctional magnetic resonance imagingMeasures of attentionCore cognitive skillsLong-term cognitive outcomesStructural brain changesSmall-moderate effect sizeFunctional network propertiesSurvivors of brain tumorsBrain tumor survivorsGraph metricsResting state dataGlobal efficiencyNeuropsychological deficitsNeuropsychological testsBrain changesGroup differencesIndependence in adulthood