2024
Testing the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging
Mendez Colmenares A, Thomas M, Anderson C, Arciniegas D, Calhoun V, Choi I, Kramer A, Li K, Lee J, Lee P, Burzynska A. Testing the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging. Neurobiology Of Aging 2024, 141: 21-33. PMID: 38810596, PMCID: PMC11290458, DOI: 10.1016/j.neurobiolaging.2024.05.013.Peer-Reviewed Original ResearchDisconnection hypothesisVirginia Cognitive Aging ProjectHypothesis of cognitive agingFractional anisotropyAssociated with reduced memory performanceDeterioration of white matterAge-related memory lossPrefrontal white matterGenu of the corpus callosumMyelin water fractionVoxel-wise analysisWhite matterCorpus callosumExecutive functionCognitive agingDiffusion tensor imagingMemory performancePrefrontal WMStructural equation modelingWM microstructureAge differencesProcessing speedStructural disconnectionCognitive declineHealthy participantsMIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume
Blokland G, Maleki N, Jovicich J, Mesholam-Gately R, DeLisi L, Turner J, Shenton M, Voineskos A, Kahn R, Roffman J, Holt D, Ehrlich S, Kikinis Z, Dazzan P, Murray R, Lee J, Sim K, Lam M, de Zwarte S, Walton E, Kelly S, Picchioni M, Bramon E, Makris N, David A, Mondelli V, Reinders A, Oykhman E, Morris D, Gill M, Corvin A, Cahn W, Ho N, Liu J, Gollub R, Manoach D, Calhoun V, Sponheim S, Buka S, Cherkerzian S, Thermenos H, Dickie E, Ciufolini S, Marques T, Crossley N, Purcell S, Smoller J, van Haren N, Toulopoulou T, Donohoe G, Goldstein J, Keshavan M, Petryshen T, del Re E. MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume. International Journal Of Clinical And Health Psychology 2024, 24: 100458. PMID: 38623146, PMCID: PMC11017057, DOI: 10.1016/j.ijchp.2024.100458.Peer-Reviewed Original ResearchIncreased LV volumesLV ratioLateral ventricleLV volumesCorpus callosumEphrin pathwaysSZ probandsHallmarks of schizophreniaEnlarged lateral ventriclesSNP-based heritability estimatesGlobal Assessment of FunctioningBrain MRI scansGlobal functioningCorpus callosum volumeAssessment of FunctioningClinical dataCC abnormalitiesMicroRNA MIR137MRI scansCC volumeGlobal assessmentMid-anteriorInverse correlationSchizophreniaMIR137
2023
Symmetric data-driven fusion of diffusion tensor MRI: Age differences in white matter
Colmenares A, Hefner M, Calhoun V, Salerno E, Fanning J, Gothe N, McAuley E, Kramer A, Burzynska A. Symmetric data-driven fusion of diffusion tensor MRI: Age differences in white matter. Frontiers In Neurology 2023, 14: 1094313. PMID: 37139071, PMCID: PMC10149813, DOI: 10.3389/fneur.2023.1094313.Peer-Reviewed Original ResearchDiffusion tensor imagingAge differencesExamination of age differencesPattern of age differencesFractional anisotropyRadial diffusivityJoint independent component analysisCognitively healthy adultsWhite matterDiffusion tensor imaging parametersFluid abilitiesPrefrontal WMProcessing speedDiagnostic classificationWM pathologyDiffusion tensor imaging datasetsAging WMUnimodal analysisTensor imagingIndependent component analysisClinical samplesHealthy agingCognitionCorpus callosumHealthy adults