Identifying psychosis subtypes use individualized covariance structural differential networks and multi-site clustering
Ji Y, Pearlson G, Bustillo J, Kochunov P, Turner J, Jiang R, Shao W, Zhang X, Fu Z, Li K, Liu Z, Xu X, Zhang D, Qi S, Calhoun V. Identifying psychosis subtypes use individualized covariance structural differential networks and multi-site clustering. Schizophrenia Research 2023, 264: 130-139. PMID: 38128344, DOI: 10.1016/j.schres.2023.12.013.Peer-Reviewed Original ResearchPsychosis subtypesSchizoaffective disorderBipolar disorderClinical phenotypeFirst-degree relativesTemporal-occipital cortexAmygdala-hippocampusClinical symptomsNeuroimaging featuresBipolar-Schizophrenia NetworkBrain alterationsHealthy controlsIntermediate Phenotypes (B-SNIP) consortiumOccipital cortexDecreased connectivitySubtypesStructural covarianceFractional amplitudeSubtype IILow-frequency fluctuationsNeurobiological heterogeneityGreater predispositionPsychosis spectrumGroup differencesDiagnostic classificationA Brainwide Risk Score for Psychiatric Disorder Evaluated in a Large Adolescent Population Reveals Increased Divergence Among Higher-Risk Groups Relative to Control Participants
Yan W, Pearlson G, Fu Z, Li X, Iraji A, Chen J, Sui J, Volkow N, Calhoun V. A Brainwide Risk Score for Psychiatric Disorder Evaluated in a Large Adolescent Population Reveals Increased Divergence Among Higher-Risk Groups Relative to Control Participants. Biological Psychiatry 2023, 95: 699-708. PMID: 37769983, PMCID: PMC10942727, DOI: 10.1016/j.biopsych.2023.09.017.Peer-Reviewed Original ResearchFunctional network connectivityHealthy control individualsPsychiatric disordersRisk scoreEarly psychosisPsychiatric riskControl individualsStudy participantsHigh-risk groupMajor depressive disorderHigh-risk patternsPsychiatric risk assessmentCognitive Development StudyUnaffected adolescentsAdolescent Brain Cognitive Development (ABCD) studyLarge adolescent populationDepressive disorderHigh riskPsychosis scoresBipolar disorderPotential biomarkersEarly screeningPsychiatric vulnerabilityAdolescent populationDisorders