2018
Role of NOD2 in antiphospholipid antibody-induced and bacterial MDP amplification of trophoblast inflammation
Mulla MJ, Pasternak MC, Salmon JE, Chamley LW, Abrahams VM. Role of NOD2 in antiphospholipid antibody-induced and bacterial MDP amplification of trophoblast inflammation. Journal Of Autoimmunity 2018, 98: 103-112. PMID: 30594350, DOI: 10.1016/j.jaut.2018.12.003.Peer-Reviewed Original ResearchConceptsMuramyl dipeptideAbsence of aPLAnti-angiogenic profileNovel danger signalPresence of aPLRole of NOD2IL-1β expressionMaternal-fetal interfaceActivation of NOD2IL-1β productionBacterial muramyl dipeptideAntiphospholipid antibodiesCommon bacterial componentsPregnancy complicationsPregnancy outcomesAdverse outcomesIL-1βTrophoblast responsesExtravillous trophoblastsHigh riskPreeclampsiaDanger signalsBacterial infectionsVEGF secretionInflammation
2006
Toll-Like Receptors and Pregnancy
Abrahams V, Mor G. Toll-Like Receptors and Pregnancy. Medical Intelligence Unit 2006, 15-25. DOI: 10.1007/0-387-34944-8_2.Peer-Reviewed Original ResearchMaternal-fetal interfaceToll-like receptorsCertain pregnancy complicationsInnate immune cellsInnate immune responseInnate immune systemAllogenic fetusIntrauterine infectionPregnancy complicationsTrophoblast responsesImmune cellsClinical studiesImmune responseImmune systemTrophoblast cellsHost defensePossible pathogensPregnancyStrong associationReceptorsCellsComplicationsPathogensTLRFetuses