2013
An Injury-Responsive Gata4 Program Shapes the Zebrafish Cardiac Ventricle
Gupta V, Gemberling M, Karra R, Rosenfeld GE, Evans T, Poss KD. An Injury-Responsive Gata4 Program Shapes the Zebrafish Cardiac Ventricle. Current Biology 2013, 23: 1221-1227. PMID: 23791730, PMCID: PMC3759223, DOI: 10.1016/j.cub.2013.05.028.Peer-Reviewed Original ResearchConceptsVentricular wallCortical layersNormal cardiac functionHeart regenerationHeart failureCardiac damageCardiac functionCardiac ventriclesExpression of GATA4Cellular mechanismsBiomechanical stressCardiomyocytesTransgenic inhibitionGATA4 activityMuscleVentricleZebrafish heart regenerationAdultsDynamic cellular mechanismsClonal analysisOrganismal growthDevelopmental programClonal plasticityJuvenile zebrafishGATA4
2012
Clonally dominant cardiomyocytes direct heart morphogenesis
Gupta V, Poss KD. Clonally dominant cardiomyocytes direct heart morphogenesis. Nature 2012, 484: 479-484. PMID: 22538609, PMCID: PMC3340018, DOI: 10.1038/nature11045.Peer-Reviewed Original ResearchConceptsStem cell populationVertebrate embryosVertebrate organsNew lineageClonal dominanceEmbryonic structuresClonal analysisTissue architectureCell populationsProliferative behaviorIndividual cardiomyocytesAdult formKey mechanismCardiomyocytesAdult cardiac structureCirculatory needsMorphogenesisLineagesEmbryosMaturesDominanceOrgansVariable sizeThick wallsLateral expansion
2011
tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration
Kikuchi K, Gupta V, Wang J, Holdway JE, Wills AA, Fang Y, Poss KD. tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. Development 2011, 138: 2895-2902. PMID: 21653610, PMCID: PMC3119303, DOI: 10.1242/dev.067041.Peer-Reviewed Original ResearchConceptsHeart developmentZebrafish heart developmentRecent lineage-tracing studiesLineage-tracing studiesEmbryonic developmentUpstream sequencesHeart regenerationCell typesEpicardial cellsDevelopmental potentialCardiac muscle cellsZebrafishTCF21Muscle cellsPerivascular cellsCellsFateRegenerationCardiogenesisLarvalEpicardial tissueSequenceExpressionDevelopment