Clonally dominant cardiomyocytes direct heart morphogenesis
Gupta V, Poss KD. Clonally dominant cardiomyocytes direct heart morphogenesis. Nature 2012, 484: 479-484. PMID: 22538609, PMCID: PMC3340018, DOI: 10.1038/nature11045.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineageClone CellsHeartHeart InjuriesHeart VentriclesMorphogenesisMyocardiumMyocytes, CardiacRegenerationStaining and LabelingZebrafishConceptsStem cell populationVertebrate embryosVertebrate organsNew lineageClonal dominanceEmbryonic structuresClonal analysisTissue architectureCell populationsProliferative behaviorIndividual cardiomyocytesAdult formKey mechanismCardiomyocytesAdult cardiac structureCirculatory needsMorphogenesisLineagesEmbryosMaturesDominanceOrgansVariable sizeThick wallsLateral expansion