2020
Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Shabanova V, Raffini LJ, Kandil SB, Li S, Pinto MG, Cholette JM, Hanson SJ, Nellis ME, Silva CT, Chima R, Sharathkumar A, Thomas KA, McPartland T, Tala JA, Spinella PC. Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2020, 49: e235-e246. PMID: 33372745, PMCID: PMC7902342, DOI: 10.1097/ccm.0000000000004784.Peer-Reviewed Original ResearchConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisDeep venous thrombosisUsual care armCentral venous cathetersVenous thrombosisClinical trialsEnoxaparin armCare armVenous cathetersEarly prophylaxisIll childrenThrombin generationPhase 2bCatheter-Associated ThrombosisInternational units/mLAnti-Xa levelsCritically Ill ChildrenRandomized clinical trialsEndogenous thrombin potentialRelevant bleedingUsual careTrial armsRisk ratioThrombin potential
2019
Parenteral Antibiotic Therapy Duration in Young Infants With Bacteremic Urinary Tract Infections
Desai S, Aronson PL, Shabanova V, Neuman MI, Balamuth F, Pruitt CM, DePorre AG, Nigrovic LE, Rooholamini SN, Wang ME, Marble RD, Williams DJ, Sartori L, Leazer RC, Mitchell C, Shah SS. Parenteral Antibiotic Therapy Duration in Young Infants With Bacteremic Urinary Tract Infections. Pediatrics 2019, 144: e20183844. PMID: 31431480, PMCID: PMC6855812, DOI: 10.1542/peds.2018-3844.Peer-Reviewed Original ResearchConceptsBacteremic urinary tract infectionUrinary tract infectionAntibiotic durationParenteral antibioticsTract infectionsFrequent recurrent urinary tract infectionsYoung infantsMulticenter retrospective cohort studyRecurrent urinary tract infectionsAntibiotic therapy durationShort-course groupRetrospective cohort studyLong-course therapyMarginal structural modelsHospital reutilizationUTI recurrenceOral antibioticsCohort studyParenteral therapyPatient characteristicsTherapy durationUrine cultureChildren's HospitalWeighted populationEarly conversion