2013
Effectiveness of first-line antiretroviral therapy and correlates of longitudinal changes in CD4 and viral load among HIV-infected children in Ghana
Barry O, Powell J, Renner L, Bonney EY, Prin M, Ampofo W, Kusah J, Goka B, Sagoe K, Shabanova V, Paintsil E. Effectiveness of first-line antiretroviral therapy and correlates of longitudinal changes in CD4 and viral load among HIV-infected children in Ghana. BMC Infectious Diseases 2013, 13: 476. PMID: 24119088, PMCID: PMC3852953, DOI: 10.1186/1471-2334-13-476.Peer-Reviewed Original ResearchConceptsPediatric HIV clinicResource-limited countriesViral loadDrug-resistant mutationsVirologic failureHIV clinicFirst-line antiretroviral therapyHIV viral load monitoringCohort of HIVFirst-line ARTFirst-line regimenGenotypic resistance testingHIV viral loadInitiation of therapyType of regimenViral load monitoringSeverity of illnessViral load testingVirologic treatment failurePrimary care giversAntiretroviral therapyART regimensCD4 countTreatment failureWHO criteria
2010
Determinants of Individual Variation in Intracellular Accumulation of Anti-HIV Nucleoside Analog Metabolites
Paintsil E, Dutschman GE, Hu R, Grill SP, Wang CJ, Lam W, Li FY, Ghebremichael M, Northrup V, Cheng YC. Determinants of Individual Variation in Intracellular Accumulation of Anti-HIV Nucleoside Analog Metabolites. Antimicrobial Agents And Chemotherapy 2010, 55: 895-903. PMID: 21078952, PMCID: PMC3028801, DOI: 10.1128/aac.01303-10.Peer-Reviewed Original ResearchConceptsNucleoside analoguesPeripheral blood mononuclear cellsAntiretroviral drug discoveryThymidine kinase 1 activityBlood mononuclear cellsConcentrations of AZTMetabolite concentrationsIntracellular concentrationAntiretroviral therapyClinical responseMononuclear cellsHealthy donorsHIV therapyTherapy needTriphosphate metaboliteAZT monophosphateAnalogue metabolitesCellular kinasesCassette (ABC) transport proteinsInverse correlationDemographic characteristicsAZTIntracellular accumulationKinase 1 activityIndividual variation