2024
Hospital Readmissions Among Infants With Neonatal Opioid Withdrawal Syndrome
Gaither J, Drago M, Grossman M, Li Y, Shabanova V, Xu X, Leventhal J. Hospital Readmissions Among Infants With Neonatal Opioid Withdrawal Syndrome. JAMA Network Open 2024, 7: e2435074. PMID: 39316398, PMCID: PMC11423163, DOI: 10.1001/jamanetworkopen.2024.35074.Peer-Reviewed Original ResearchConceptsNeonatal opioid withdrawal syndromeOpioid withdrawal syndromeWithdrawal syndromeCohort studyHospital readmissionLow birth weightReadmission ratesRetrospective cohort studyIncreased risk of readmissionNationwide Readmissions DatabaseClinical Modification codesGestational ageOdds of readmissionMultiple gestationsFull-termInternational Classification of DiseasesRisk of readmissionHospital discharge recordsBirth weightSurvey-weighted logistic regressionType of insuranceIncreased 5-foldIncreased riskReadmissions DatabaseYear of birth
2022
North American Biliary Stricture Management Strategies in Children After Liver Transplantation: A Multicenter Analysis From the Society of Pediatric Liver Transplantation (SPLIT) Registry
Valentino PL, Wang T, Shabanova V, Ng VL, Bucuvalas JC, Feldman AG, Gonzalez‐Peralta R, Gupta NA, Miloh TA, Mohammad S, Pace E, Sundaram SS, Yazigi NA, Soltys K, Transplantation S. North American Biliary Stricture Management Strategies in Children After Liver Transplantation: A Multicenter Analysis From the Society of Pediatric Liver Transplantation (SPLIT) Registry. Liver Transplantation 2022, 28: 819-833. PMID: 34837468, PMCID: PMC10167704, DOI: 10.1002/lt.26379.Peer-Reviewed Original ResearchConceptsEndoscopic retrograde cholangiopancreatographyPercutaneous transhepatic cholangiographyPediatric Liver Transplantation (SPLIT) registryHepatic artery thrombosisLiver transplantationAnastomotic strictureBiliary stricturesStricture resolutionArtery thrombosisGraft survivalTransplantation RegistryPediatric liver transplantation recipientsLiver transplantation recipientsPediatric liver transplantationRisk of recurrenceAnalysis of outcomesAllograft salvageBiliary outcomesExtrahepatic stricturesGraft lossTransplantation recipientsMulticenter analysisTranshepatic cholangiographyRetrograde cholangiopancreatographyOperative reportsDoes Maternal Incarceration Impact Infants with Neonatal Abstinence Syndrome?
Drago MJ, Shabanova V, Hochreiter D, Grossman M, Mercurio M. Does Maternal Incarceration Impact Infants with Neonatal Abstinence Syndrome? Maternal And Child Health Journal 2022, 26: 1095-1103. PMID: 35088297, DOI: 10.1007/s10995-021-03356-4.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidFemaleHumansInfant, NewbornLength of StayMorphineNeonatal Abstinence SyndromeOpioid-Related DisordersPregnancyRetrospective StudiesConceptsNeonatal abstinence syndromeLength of stayNon-incarcerated womenLine agentsAbstinence syndromeBreast milkMean LOSLonger LOSIncarcerated womenRetrospective cohort studyFirst-line agentsMaternal-infant dyadsSecond-line agentsPrenatal substance exposurePrenatal alcohol useCare of infantsCohort studyFinnegan scoreInfant dischargeLonger hospitalizationSubstance exposureInfantsPoisson regressionMaternal incarcerationAlcohol useLongitudinal Assessment of Global and Regional Left Ventricular Strain in Patients with Multisystem Inflammatory Syndrome in Children (MIS-C)
He M, Leone DM, Frye R, Ferdman DJ, Shabanova V, Kosiv KA, Sugeng L, Faherty E, Karnik R. Longitudinal Assessment of Global and Regional Left Ventricular Strain in Patients with Multisystem Inflammatory Syndrome in Children (MIS-C). Pediatric Cardiology 2022, 43: 844-854. PMID: 34993558, PMCID: PMC8739007, DOI: 10.1007/s00246-021-02796-7.Peer-Reviewed Original ResearchConceptsMIS-C patientsAcute phaseChronic phaseInflammatory syndromeTwo-dimensional speckle tracking echocardiographySubclinical myocardial injuryCircumferential strainMultisystem inflammatory syndromeLeft ventricular dysfunctionSingle-institution reviewSpeckle tracking echocardiographyTwo-dimensional echocardiographyCoronavirus disease 2019Future adverse eventsVentricular function parametersBasal anterolateral segmentMean GCSVentricular dysfunctionAdverse eventsFractional shorteningSignificant sequelaeVentricular strainMyocardial dysfunctionGlobal longitudinalMyocardial injury
2021
Clinical decision rule for obtaining peripheral blood cultures in febrile oncology patients
Gorfinkel L, Hansen CE, Teng W, Shabanova V, Prozora S, Rodwin R, Qadri U, Manghi T, Emerson B, Riera A. Clinical decision rule for obtaining peripheral blood cultures in febrile oncology patients. Pediatric Blood & Cancer 2021, 69: e29519. PMID: 34939321, DOI: 10.1002/pbc.29519.Peer-Reviewed Original ResearchMeSH KeywordsBacteremiaBlood CultureChildClinical Decision RulesFeverHumansModels, StatisticalNeoplasmsPrognosisProspective StudiesRetrospective StudiesConceptsPediatric emergency departmentPeripheral blood culturesPediatric oncology patientsFebrile oncology patientsClinical decision ruleOncology patientsBlood culturesBloodstream infectionsPositive peripheral blood cultureDiagnostic prediction toolsInternal validationRetrospective chart reviewAcute myeloid leukemia diagnosisRecent systematic reviewClinical prediction modelReceiver operator curveVasopressor supportActive therapyChart reviewDerivation cohortIndependent predictorsEmergency departmentPatientsSystematic reviewOperator curveA novel and accurate method for estimating umbilical arterial and venous catheter insertion length
Tambasco CJ, Shabanova V, Peterec SM, Bizzarro MJ. A novel and accurate method for estimating umbilical arterial and venous catheter insertion length. Journal Of Perinatology 2021, 41: 1633-1637. PMID: 34103672, DOI: 10.1038/s41372-021-01121-7.Peer-Reviewed Original ResearchMeSH KeywordsCatheterization, PeripheralCathetersHumansInfant, NewbornProspective StudiesRetrospective StudiesUmbilical ArteriesUmbilical VeinsUse of Pharmacologic Prophylaxis Against Venous Thromboembolism in Hospitalized Injured Children
Mahajerin A, Petty JK, Hanson SJ, Shabanova V, Faustino EVS. Use of Pharmacologic Prophylaxis Against Venous Thromboembolism in Hospitalized Injured Children. Journal Of Pediatric Hematology/Oncology 2021, 44: e349-e357. PMID: 33885041, DOI: 10.1097/mph.0000000000002167.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnticoagulantsChildHeparinHumansRetrospective StudiesRisk FactorsVenous ThromboembolismConceptsReceipt of prophylaxisRisk of VTEVenous thromboembolismInjured childrenRisk prediction modelPharmacologic prophylaxisTrauma Quality Improvement ProgramLow molecular weight heparinHospitalized injured patientsPediatric-specific evidencePractice management guidelinesRandomized clinical trialsMolecular weight heparinQuality Improvement ProgramUnfractionated heparinWeight heparinRetrospective studyInjured patientsClinical trialsProphylaxisManagement guidelinesThromboembolismPatientsHigh rateChildren
2020
Patterns of medication use at end of life by pediatric inpatients with cancer
Prozora S, Shabanova V, Ananth P, Pashankar F, Kupfer GM, Massaro SA, Davidoff AJ. Patterns of medication use at end of life by pediatric inpatients with cancer. Pediatric Blood & Cancer 2020, 68: e28837. PMID: 33306281, DOI: 10.1002/pbc.28837.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild, PreschoolFemaleHumansInfantInfant, NewbornInpatientsMaleNeoplasmsPalliative CareRetrospective StudiesTerminal CareYoung AdultConceptsMedication usePediatric inpatientsVizient Clinical Database/Resource ManagerHematopoietic stem cell transplantLife-sustaining medicationsMedication utilization patternsSymptom management medicationsUse of opioidsStem cell transplantIntensive care unitLength of stayAcademic medical centerResource use dataLast weekWarrants further studyEvidence-based approachVasopressor useEnd of lifeCare unitCell transplantMedication categoriesResuscitate statusRetrospective studyMalignancy typeOdds ratioThe association between anti-Müllerian hormone and vitamin 25(OH)D serum levels and polycystic ovarian syndrome in adolescent females
Simpson S, Seifer DB, Shabanova V, Lynn AY, Howe C, Rowe E, Caprio S, Vash-Margita A. The association between anti-Müllerian hormone and vitamin 25(OH)D serum levels and polycystic ovarian syndrome in adolescent females. Reproductive Biology And Endocrinology 2020, 18: 118. PMID: 33218348, PMCID: PMC7679991, DOI: 10.1186/s12958-020-00676-y.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-Mullerian HormoneFemaleHumansPolycystic Ovary SyndromeRegression AnalysisRetrospective StudiesRisk FactorsVitamin DYoung AdultConceptsPolycystic ovarian syndromeRotterdam diagnostic criteriaNon-PCOS groupMedian AMHOvarian syndromePCOS groupDiagnostic criteriaAnti-Müllerian hormone levelsAdolescent femalesRetrospective chart reviewTraditional clinical markersAnti-Müllerian hormoneCross-sectional studyWilcoxon rank sum testSignificant unadjusted differencesRank sum testD deficiencyChart reviewClinical featuresEndocrinology clinicSerum levelsAdjusted analysisUnadjusted comparisonsInsurance typeSurrogate markerRisks of venous thrombosis and bleeding in critically ill adolescents after trauma or major surgery
Hanson SJ, Mahajerin A, Petty JK, Shabanova V, Faustino EVS. Risks of venous thrombosis and bleeding in critically ill adolescents after trauma or major surgery. Journal Of Pediatric Surgery 2020, 56: 302-308. PMID: 32713711, DOI: 10.1016/j.jpedsurg.2020.06.037.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnticoagulantsChildCritical IllnessHumansRetrospective StudiesRisk FactorsVenous ThromboembolismVenous ThrombosisConceptsCentral venous catheterizationVenous thromboembolismMajor surgeryMechanical ventilationAnatomic sitesHigh riskIll adolescentsVirtual Pediatric Systems databasePediatric intensive care unitRisk of VTERetrospective cohort studyIntensive care unitMixed-effects logistic regressionEffects logistic regressionPharmacologic prophylaxisAdjusted riskCohort studyVenous thrombosisCare unitVenous catheterizationLower riskSurgeryLevel IILogistic regressionTraumaFactors in Early Feeding Practices That May Influence Growth and the Challenges That Arise in Growth Outcomes Research
Fabrizio V, Shabanova V, Taylor SN. Factors in Early Feeding Practices That May Influence Growth and the Challenges That Arise in Growth Outcomes Research. Nutrients 2020, 12: 1939. PMID: 32629763, PMCID: PMC7399918, DOI: 10.3390/nu12071939.Peer-Reviewed Original ResearchConceptsWeeks gestational ageGestational agePreterm infantsEarly feeding practicesInfant growth trajectoriesFetal growth chartsSingle-center investigationInitial hospitalizationParenteral nutritionImproved outcomesInclusion criteriaFeeding practicesGrowth chartsNutritional practicesFirst weekHospital growthNutritional factorsInfantsQuartileCenter investigationLess daysOutcomes researchCaloric densityHospitalizationCohort effects
2019
Parenteral Antibiotic Therapy Duration in Young Infants With Bacteremic Urinary Tract Infections
Desai S, Aronson PL, Shabanova V, Neuman MI, Balamuth F, Pruitt CM, DePorre AG, Nigrovic LE, Rooholamini SN, Wang ME, Marble RD, Williams DJ, Sartori L, Leazer RC, Mitchell C, Shah SS. Parenteral Antibiotic Therapy Duration in Young Infants With Bacteremic Urinary Tract Infections. Pediatrics 2019, 144: e20183844. PMID: 31431480, PMCID: PMC6855812, DOI: 10.1542/peds.2018-3844.Peer-Reviewed Original ResearchConceptsBacteremic urinary tract infectionUrinary tract infectionAntibiotic durationParenteral antibioticsTract infectionsFrequent recurrent urinary tract infectionsYoung infantsMulticenter retrospective cohort studyRecurrent urinary tract infectionsAntibiotic therapy durationShort-course groupRetrospective cohort studyLong-course therapyMarginal structural modelsHospital reutilizationUTI recurrenceOral antibioticsCohort studyParenteral therapyPatient characteristicsTherapy durationUrine cultureChildren's HospitalWeighted populationEarly conversion
2018
Reducing Radiation Exposure in Cardiac Catheterizations for Congenital Heart Disease
Patel C, Grossman M, Shabanova V, Asnes J. Reducing Radiation Exposure in Cardiac Catheterizations for Congenital Heart Disease. Pediatric Cardiology 2018, 40: 638-649. PMID: 30542920, DOI: 10.1007/s00246-018-2039-9.Peer-Reviewed Original ResearchConceptsCatheterization labRadiation exposureCardiac catheterizationYale-New Haven Children's HospitalDAP/Patent ductus arteriosusAtrial septal defectCongenital heart diseaseDose area productSystems-based interventionsCardiac catheterization labCongenital cardiac catheterizationTotal air kermaPost-intervention dataRadiation dose reductionAir kermaQuality improvement strategiesDuctus arteriosusTranscatheter pulmonaryChildren's HospitalDA dosesSeptal defectHeart diseaseLow fluoroscopyProcedure typeUS National Trends in Pediatric Deaths From Prescription and Illicit Opioids, 1999-2016
Gaither JR, Shabanova V, Leventhal JM. US National Trends in Pediatric Deaths From Prescription and Illicit Opioids, 1999-2016. JAMA Network Open 2018, 1: e186558. PMID: 30646334, PMCID: PMC6324338, DOI: 10.1001/jamanetworkopen.2018.6558.Peer-Reviewed Original ResearchConceptsOpioid poisoningPediatric deathsMortality rateUS national trendsPublic health problemPediatric mortality rateNational trendsPublic health officialsIllicit opioidsPrescription opioidsAge-specific mortality ratesOpioid deathsOpioid epidemicMAIN OUTCOMEOpioidsHealth problemsOpioid crisisPoisson regressionSynthetic opioidsDisease controlMortality dataHealth officialsDeathMedical facilitiesChildrenFactors Associated with Adverse Outcomes among Febrile Young Infants with Invasive Bacterial Infections
Pruitt CM, Neuman MI, Shah SS, Shabanova V, Woll C, Wang ME, Alpern ER, Williams DJ, Sartori L, Desai S, Leazer RC, Marble RD, McCulloh RJ, DePorre AG, Rooholamini SN, Lumb CE, Balamuth F, Shin S, Aronson PL, Collaborative F, Nigrovic L, Browning W, Mitchell C, Peaper D, Feldman E. Factors Associated with Adverse Outcomes among Febrile Young Infants with Invasive Bacterial Infections. The Journal Of Pediatrics 2018, 204: 177-182.e1. PMID: 30297292, PMCID: PMC6309646, DOI: 10.1016/j.jpeds.2018.08.066.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBacteremiaCohort StudiesFemaleFeverHumansInfantInfant MortalityInfant, NewbornMaleMeningitis, BacterialRetrospective StudiesRisk FactorsConceptsInvasive bacterial infectionsFebrile young infantsAdverse outcomesBacterial meningitisYoung infantsIll appearanceFebrile infantsBacterial infectionsRetrospective cohort studyMedical record reviewLocal microbiology laboratoryMixed-effects logistic regressionElectronic medical record systemDays of ageIll appearingNeurologic sequelaeCohort studyMedical record systemClinical factorsMedication receiptMechanical ventilationRecord reviewClinical dataInclusion criteriaMeningitis
2017
Comparison of valvar and right ventricular function following transcatheter and surgical pulmonary valve replacement
Li WF, Pollard H, Karimi M, Asnes JD, Hellenbrand WE, Shabanova V, Weismann CG. Comparison of valvar and right ventricular function following transcatheter and surgical pulmonary valve replacement. Congenital Heart Disease 2017, 13: 140-146. PMID: 29148206, PMCID: PMC5796854, DOI: 10.1111/chd.12544.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBioprosthesisCardiac CatheterizationChildChild, PreschoolEchocardiographyFemaleFollow-Up StudiesHeart Valve Prosthesis ImplantationHeart VentriclesHumansMaleMiddle AgedPulmonary ValvePulmonary Valve InsufficiencyRetrospective StudiesTime FactorsTreatment OutcomeVentricular Function, RightVentricular RemodelingYoung AdultConceptsRight ventricular outflow tract obstructionPulmonary valve replacementSurgical pulmonary valve replacementRight ventricular functionPulmonic insufficiencyVentricular functionTC groupRV functionSurgical groupValve replacementRV sizeVentricular outflow tract obstructionYale-New Haven HospitalOutflow tract obstructionTract obstructionPatient ageRetrospective reviewSurgical valvesPostoperative declinePulmonary valveHigh riskValve functionPatientsFirst choiceTime pointsRisk factors for tracheostomy requirement in extremely low birth weight infants
Levit OL, Shabanova V, Bazzy-Asaad A, Bizzarro MJ, Bhandari V. Risk factors for tracheostomy requirement in extremely low birth weight infants. The Journal Of Maternal-Fetal & Neonatal Medicine 2017, 31: 447-452. PMID: 28139937, DOI: 10.1080/14767058.2017.1287895.Peer-Reviewed Original ResearchMeSH KeywordsAirway ExtubationCase-Control StudiesFemaleGestational AgeHumansInfantInfant, Extremely Low Birth WeightInfant, Extremely PrematureInfant, NewbornIntubation, IntratrachealMalePregnancyRespiration, ArtificialRetrospective StudiesRisk FactorsSeverity of Illness IndexTime FactorsTracheostomyConceptsLow birth weight infantsOdds of tracheostomyBirth weight infantsELBW infantsWeight infantsEndotracheal tubeRisk of tracheostomyPresence of comorbiditiesUse of steroidsCase-control studyConditional logistic regressionNumber of intubationsGreater cumulative exposureIntubation episodesTracheostomy requirementExtubation attemptGestational ageEpisodes/Risk factorsTracheostomyPrevious episodesCumulative exposurePoisson regressionCumulative daysInfants
2015
Neonatal Sepsis 2004-2013: The Rise and Fall of Coagulase-Negative Staphylococci
Bizzarro MJ, Shabanova V, Baltimore RS, Dembry LM, Ehrenkranz RA, Gallagher PG. Neonatal Sepsis 2004-2013: The Rise and Fall of Coagulase-Negative Staphylococci. The Journal Of Pediatrics 2015, 166: 1193-1199. PMID: 25919728, PMCID: PMC4413005, DOI: 10.1016/j.jpeds.2015.02.009.Peer-Reviewed Original ResearchConceptsEarly-onset sepsisLate-onset sepsisNeonatal intensive care unitCoagulase-negative staphylococciIntensive care unitCare unitLevel IV neonatal intensive care unitEpisodes of sepsisLow birth weightInfection prevention initiativesInfection prevention effortsPercent of casesGroup B streptococciHospital courseSepsis episodesMost infantsBirth weightCommon organismB streptococciSepsisOutcome dataAdditional surveillancePrevention effortsStudy periodInfants
2014
Effect of vitamin D–binding protein genotype on the development of asthma in children
Navas-Nazario A, Li FY, Shabanova V, Weiss P, Cole DE, Carpenter TO, Bazzy-Asaad A. Effect of vitamin D–binding protein genotype on the development of asthma in children. Annals Of Allergy Asthma & Immunology 2014, 112: 519-524. PMID: 24745702, PMCID: PMC4070170, DOI: 10.1016/j.anai.2014.03.017.Peer-Reviewed Original ResearchMeSH KeywordsAsthmaChild, PreschoolCholestanetriol 26-MonooxygenaseConnecticutCytochrome P450 Family 2FemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHispanic or LatinoHumansInfantMalePolymorphism, Single NucleotideReceptors, CalcitriolRetrospective StudiesVitamin DVitamin D-Binding ProteinConceptsDevelopment of asthmaVitamin DGC genotypeVitamin D metabolite levelsRetrospective medical record reviewVitamin D insufficiencyMedical record reviewCurrent clinical dataSingle nucleotide polymorphismsVitamin D metabolitesGC single nucleotide polymorphismsHispanic populationPotential vitamin DMonths of ageD insufficiencyAsthma morbidityHealthy infantsRecord reviewD metabolitesHealthy childrenInflammatory diseasesNucleotide polymorphismsClinical dataProtective effectAsthmaClinical and Laboratory Factors That Predict Death in Very Low Birth Weight Infants Presenting With Late-onset Sepsis
Levit O, Bhandari V, Li FY, Shabanova V, Gallagher PG, Bizzarro MJ. Clinical and Laboratory Factors That Predict Death in Very Low Birth Weight Infants Presenting With Late-onset Sepsis. The Pediatric Infectious Disease Journal 2014, 33: 143-146. PMID: 24418836, PMCID: PMC3917323, DOI: 10.1097/inf.0000000000000024.Peer-Reviewed Original ResearchConceptsLate-onset sepsisLow birth weight infantsBirth weight infantsIndependent risk factorLaboratory factorsWeight infantsVLBW infantsRisk factorsCases of LOSEpisodes of LOSRisk of LOSFungal LOSNeonatal intensive care unitMultivariate logistic regression analysisSepsis-related deathsIntensive care unitOnset of illnessSepsis-associated mortalityGram-positive infectionsLogistic regression analysisOnset of diseasePresentation of illnessComposite risk profileLaboratory signsNecrotizing enterocolitis