A Prospective Study of the Effects of Sex Hormones on Lung Function and Inflammation in Women with Cystic Fibrosis.
Holtrop M, Heltshe S, Shabanova V, Keller A, Schumacher L, Fernandez L, Jain R. A Prospective Study of the Effects of Sex Hormones on Lung Function and Inflammation in Women with Cystic Fibrosis. Annals Of The American Thoracic Society 2021, 18: 1158-1166. PMID: 33544657, DOI: 10.1513/annalsats.202008-1064oc.Peer-Reviewed Original ResearchConceptsLung functionSex hormonesCystic fibrosisInflammatory markersProinflammatory cytokinesHormone concentrationsEthinyl estradiol/norethindroneRegular menstrual cyclesSubset of subjectsHormone contraceptionPeak estrogenAirway inflammationPulmonary exacerbationsInflammatory biomarkersRespiratory symptomsHormonal contraceptivesHormonal contraceptionProspective studyContraceptive pillsMenstrual cycleSymptom questionnaireWorse outcomesStudy visitRespiratory pathogensClinical impact