2021
Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Raffini LJ, Hanson SJ, Cholette JM, Pinto MG, Li S, Kandil SB, Nellis ME, Shabanova V, Silva CT, Tala JA, McPartland T, Spinella PC. Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2021, 49: e369-e380. PMID: 33566465, PMCID: PMC7979442, DOI: 10.1097/ccm.0000000000004848.Peer-Reviewed Original ResearchConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisCentral venous cathetersEfficacy of prophylaxisDeep venous thrombosisAge-dependent heterogeneityAnti-Xa levelsVenous cathetersVenous thrombosisFactor VIII activityThrombin generationPlatelet countClinical trialsIll childrenPhase 2bVIII activityLow factor VIII activityCatheter-Associated ThrombosisInternational units/mLMinimum platelet countOlder childrenCritically Ill ChildrenEndogenous thrombin potentialHigher platelet countsPost Hoc Analysis
2020
Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Shabanova V, Raffini LJ, Kandil SB, Li S, Pinto MG, Cholette JM, Hanson SJ, Nellis ME, Silva CT, Chima R, Sharathkumar A, Thomas KA, McPartland T, Tala JA, Spinella PC. Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2020, 49: e235-e246. PMID: 33372745, PMCID: PMC7902342, DOI: 10.1097/ccm.0000000000004784.Peer-Reviewed Original ResearchConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisDeep venous thrombosisUsual care armCentral venous cathetersVenous thrombosisClinical trialsEnoxaparin armCare armVenous cathetersEarly prophylaxisIll childrenThrombin generationPhase 2bCatheter-Associated ThrombosisInternational units/mLAnti-Xa levelsCritically Ill ChildrenRandomized clinical trialsEndogenous thrombin potentialRelevant bleedingUsual careTrial armsRisk ratioThrombin potentialBayesian analysis of the epidemiology of bleeding in critically ill children
Greenway T, Eysenbach L, Shabanova V, Faustino EVS. Bayesian analysis of the epidemiology of bleeding in critically ill children. Journal Of Critical Care 2020, 63: 133-138. PMID: 33012582, PMCID: PMC8005501, DOI: 10.1016/j.jcrc.2020.09.028.Peer-Reviewed Original ResearchConceptsISTH definitionIll childrenPediatric intensive care unitProspective cohort studyIntensive care unitRelevant bleedingCohort studyCare unitMechanical ventilationEntire cohortPediatric intensivistsSurvey definitionChildrenEpidemiologyInternational SocietyPrimary analytic toolsConcordanceFindingsBleedingIntensivistsThrombosisHigh frequencyHaemostasisCohortYears
2016
Prediction of Catheter-Associated Thrombosis in Critically Ill Children
Marquez A, Shabanova V, Faustino EV. Prediction of Catheter-Associated Thrombosis in Critically Ill Children. Pediatric Critical Care Medicine 2016, 17: e521-e528. PMID: 27662566, DOI: 10.1097/pcc.0000000000000958.Peer-Reviewed Original ResearchConceptsCatheter-associated thrombosisCentral venous cathetersVenous cathetersIll childrenRecent surgeryHigh riskCatheter-associated deep venous thrombosisMulticenter prospective cohort studyBlood product transfusionDeep venous thrombosisProspective cohort studyCritically Ill ChildrenSeverity of illnessRisk prediction modelProduct transfusionCohort studyVenous thrombosisGroup of childrenSubclavian veinActive surveillanceThrombosisCatheterSecondary analysisLogistic regressionCharacteristic curve
2013
The SNAP index does not correlate with the State Behavioral Scale in intubated and sedated children
Thompson C, Shabanova V, Giuliano JS. The SNAP index does not correlate with the State Behavioral Scale in intubated and sedated children. Pediatric Anesthesia 2013, 23: 1174-1179. PMID: 24103039, PMCID: PMC3880626, DOI: 10.1111/pan.12258.Peer-Reviewed Original ResearchConceptsState Behavioral ScalePediatric intensive care unitSNAP indexSedation levelIll childrenIll pediatric patientsIntensive care unitLevel of sedationPediatric critical careBehavioral scalesIntravenous sedationPediatric patientsSNAP-IICare unitSBS scoresSubjective sedationBedside nursesSedated childrenCritical careObservational studySedationScoring toolInformed consentPatientsBrain activity
2012
Incidence and Acute Complications of Asymptomatic Central Venous Catheter–Related Deep Venous Thrombosis in Critically Ill Children
Faustino EV, Spinella PC, Li S, Pinto MG, Stoltz P, Tala J, Card ME, Northrup V, Baker KE, Goodman TR, Chen L, Silva CT. Incidence and Acute Complications of Asymptomatic Central Venous Catheter–Related Deep Venous Thrombosis in Critically Ill Children. The Journal Of Pediatrics 2012, 162: 387-391. PMID: 22883418, PMCID: PMC3575007, DOI: 10.1016/j.jpeds.2012.06.059.Peer-Reviewed Original ResearchConceptsCVC-related deep venous thrombosisDeep venous thrombosisCentral venous cathetersIntensive care unitAcute complicationsIll childrenVenous cathetersVenous thrombosisCare unitPediatric intensive care unitProspective cohort studyChronic complicationsHospital lengthCohort studyPatient demographicsPulmonary embolismCompression ultrasonographyMechanical ventilationHigher oddsCurrent incidenceColor DopplerComplicationsCVC characteristicsLarger studyThrombosis
2011
Survey of pharmacologic thromboprophylaxis in critically ill children*
Faustino EV, Patel S, Thiagarajan RR, Cook DJ, Northrup V, Randolph AG. Survey of pharmacologic thromboprophylaxis in critically ill children*. Critical Care Medicine 2011, 39: 1773-1778. PMID: 21423003, PMCID: PMC3118917, DOI: 10.1097/ccm.0b013e3182186ec0.Peer-Reviewed Original ResearchConceptsPediatric intensive care unitIntensive care unitCare unitIll childrenPharmacologic thromboprophylaxisPediatric intensive care unit patientsIntensive care unit patientsPresence of hypercoagulabilityDeep venous thrombosisCare unit patientsEvidence-based guidelinesCross-sectional self-administered surveyRigorous randomized trialsMajor bleedingLack of evidenceUnit patientsPatient factorsVenous thrombosisCavopulmonary anastomosisRandomized trialsWeight heparinPediatric intensivistsThromboprophylaxisInfant scenarioInvasive interventions“Change, before you have to.”–Jack Welch, Former CEO, General Electric*
Faustino EV, Lawson KA, Northrup V, Higgerson RA. “Change, before you have to.”–Jack Welch, Former CEO, General Electric*. Critical Care Medicine 2011, 40: 2227-2228. PMID: 21336130, PMCID: PMC3101274, DOI: 10.1097/ccm.0b013e31820eb8a1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsCase-Control StudiesCatheterization, Central VenousCause of DeathChildChild, PreschoolCritical CareCritical IllnessFemaleHospital MortalityHumansInfantIntensive Care Units, PediatricMalePrognosisReference ValuesRespiration, ArtificialRetrospective StudiesRisk AssessmentSex FactorsSurvival AnalysisTime FactorsTreatment OutcomeVenous ThrombosisConceptsVentilator-free daysIntensive care unitCentral venous lineDeep venous thrombosisDeep vein thrombosisIndex patientsVenous thrombosisCare unitMechanical ventilationIll childrenControl patientsVein thrombosisVenous lineIntensive care unit-free daysIntensive care unit stayPrevious prospective observational studyPediatric intensive care unitCentral venous line insertionSymptomatic venous thromboembolismVenous thrombosis studyProspective observational studyAlternative outcome measuresUnit stayVenous thromboembolismCohort study