2020
A Low ω-6 to ω-3 PUFA Ratio (n–6:n–3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth
Van Name MA, Savoye M, Chick JM, Galuppo BT, Feldstein AE, Pierpont B, Johnson C, Shabanova V, Ekong U, Valentino PL, Kim G, Caprio S, Santoro N. A Low ω-6 to ω-3 PUFA Ratio (n–6:n–3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth. Journal Of Nutrition 2020, 150: 2314-2321. PMID: 32652034, PMCID: PMC7467848, DOI: 10.1093/jn/nxaa183.Peer-Reviewed Original ResearchConceptsFatty liver diseasePNPLA3 rs738409 genotypeLiver diseaseAlanine aminotransferaseRs738409 genotypeInsulin sensitivityObese youthNonalcoholic fatty liver diseaseGenotype groupsWhole-body insulin sensitivityBody insulin sensitivityLinoleic acid metabolitesHepatic fat fractionMann-Whitney U testDiet imbalanceNormocaloric dietPrimary outcomeLDL cholesterolDietary interventionFatty liverUnblinded studyObese adolescentsPUFA dietMetabolic parametersStable weight
2018
A low visceral fat proportion, independent of total body fat mass, protects obese adolescent girls against fatty liver and glucose dysregulation: a longitudinal study
Umano GR, Shabanova V, Pierpont B, Mata M, Nouws J, Tricò D, Galderisi A, Santoro N, Caprio S. A low visceral fat proportion, independent of total body fat mass, protects obese adolescent girls against fatty liver and glucose dysregulation: a longitudinal study. International Journal Of Obesity 2018, 43: 673-682. PMID: 30337653, PMCID: PMC9354568, DOI: 10.1038/s41366-018-0227-6.Peer-Reviewed Original ResearchConceptsBody fat distributionHepatic fat contentGlucose metabolismVisceral fatInsulin resistanceObese adolescentsFat distributionWhole-body insulin sensitivity indexOral glucose tolerance testTotal body fat massSubcutaneous fatIntrahepatic fat contentImpaired glucose metabolismLow ratio groupGlucose tolerance testObese adolescent girlsSubjects/methodsWeBody fat massInsulin sensitivity indexHepatic fat accumulationMajor determinantGlucose dysregulationFatty liverTolerance testFat mass
2010
Central Role of Fatty Liver in the Pathogenesis of Insulin Resistance in Obese Adolescents
D'Adamo E, Cali AM, Weiss R, Santoro N, Pierpont B, Northrup V, Caprio S. Central Role of Fatty Liver in the Pathogenesis of Insulin Resistance in Obese Adolescents. Diabetes Care 2010, 33: 1817-1822. PMID: 20668154, PMCID: PMC2909068, DOI: 10.2337/dc10-0284.Peer-Reviewed Original ResearchConceptsObese adolescentsFatty liverHFF groupVisceral fatLower whole-body insulin sensitivity indexTwo-step hyperinsulinemic-euglycemic clampWhole-body insulin sensitivity indexOral glucose tolerance testBaseline fatty acidsHepatic glucose production rateLow-dose insulinAbdominal fat distributionGlucose disposal rateIntramyocellular lipid contentGlucose tolerance testBeta-cell functionHyperinsulinemic-euglycemic clampInsulin sensitivity indexBMI z-scoreHepatic fat contentInsulin-resistant statesMagnetic resonance imagingSuppression of EGPGlucose production rateInsulin resistance