Neurology trial registrations on ClinicalTrials.gov between 2007 and 2018: A cross-sectional analysis of characteristics, early discontinuation, and results reporting
Turner BE, Magnani CJ, Frolov A, Weeks BT, Steinberg JR, Huda N, Shah LM, Zuroff L, Gu BJ, Rasmussen H, Edwards JG, Save AV, Shen M, Ren M, Bryant BR, Ma Q, Feng AY, Liang AC, Santini VE. Neurology trial registrations on ClinicalTrials.gov between 2007 and 2018: A cross-sectional analysis of characteristics, early discontinuation, and results reporting. Journal Of The Neurological Sciences 2021, 428: 117579. PMID: 34332371, DOI: 10.1016/j.jns.2021.117579.Peer-Reviewed Original ResearchConceptsEarly discontinuationClinical trialsTrial characteristicsNeurological disease burdenMultivariable logistic regressionCross-sectional analysisGovernment-funded trialsYear of completionMultivariable analysisCox regressionTreatment optionsDisease burdenHigher oddsTrial completionClinical careDiscontinuationLower riskAcademic trialsNeurology clinical trialsGreater riskLogistic regressionComparison trialEvidence baseTrialsTherapeutic focus