2020
Multi-institutional retrospective review of stereotactic radiosurgery for brain metastasis in patients with small cell lung cancer without prior brain-directed radiotherapy.
Miccio JA, Barsky A, Gao S, Verma V, Noticewala SS, Jairam V, Johnson SB, Yu JB, Hansen JE, Aneja S, An Y, Decker RH, Bulent Omay S, Li J, Kurtz GA, Alonso-Basanta M, Lee JYK, Chiang VL, Park HS. Multi-institutional retrospective review of stereotactic radiosurgery for brain metastasis in patients with small cell lung cancer without prior brain-directed radiotherapy. Journal Of Radiosurgery And SBRT 2020, 7: 19-27. PMID: 32802575, PMCID: PMC7406345.Peer-Reviewed Original ResearchWhole brain radiotherapyBrain metastasesOverall survivalNeurologic deathSmall-cell lung cancer (SCLC) brain metastasesCell lung cancer brain metastasesLung cancer brain metastasesSalvage whole brain radiotherapyMulti-institutional retrospective reviewSmall cell lung cancerMost SCLC patientsSCLC brain metastasesTime of SRSMedian overall survivalCancer brain metastasesCell lung cancerIntracranial progressionSCLC patientsUpfront radiosurgeryBrain radiationBrain radiotherapySelect patientsRetrospective reviewLung cancerStereotactic radiosurgery
2018
Multi-institutional competing risks analysis of distant brain failure and salvage patterns after upfront radiosurgery without whole brain radiotherapy for brain metastasis
McTyre E, Ayala-Peacock D, Contessa J, Corso C, Chiang V, Chung C, Fiveash J, Ahluwalia M, Kotecha R, Chao S, Attia A, Henson A, Hepel J, Braunstein S, Chan M. Multi-institutional competing risks analysis of distant brain failure and salvage patterns after upfront radiosurgery without whole brain radiotherapy for brain metastasis. Annals Of Oncology 2018, 29: 497-503. PMID: 29161348, DOI: 10.1093/annonc/mdx740.Peer-Reviewed Original ResearchConceptsDistant brain failureWhole brain radiotherapyUpfront stereotactic radiosurgerySalvage whole brain radiotherapySalvage stereotactic radiosurgeryBrain metastasesStereotactic radiosurgerySystemic diseaseMultivariate analysisBrain radiotherapyBrain failureDecreased hazardMelanoma histologyProgressive systemic diseaseWidespread systemic diseaseSystemic disease statusLower KPSSRS doseUpfront radiosurgeryIncreased hazardCompeting Risk AnalysisEarly deathAcademic centersPatientsMetastasis
2017
Radiosurgery for Brain Metastases: Changing Practice Patterns and Disparities in the United States.
Kann BH, Park HS, Johnson SB, Chiang VL, Yu JB. Radiosurgery for Brain Metastases: Changing Practice Patterns and Disparities in the United States. Journal Of The National Comprehensive Cancer Network 2017, 15: 1494-1502. PMID: 29223987, DOI: 10.6004/jnccn.2017.7003.Peer-Reviewed Original ResearchConceptsNational Cancer Data BaseStereotactic radiosurgeryBrain metastasesPractice patternsBrain radiotherapyMetastatic diseaseMetastatic non-small cell lung cancerNon-small cell lung cancerNon-SR patientsUpfront brain radiotherapyNational practice patternsProportion of patientsKaplan-Meier methodCell lung cancerProportion of facilitiesQuality of lifeChi-square testActuarial survivalIntracranial controlNeurocognitive toxicityNonprivate insuranceSRS useNCDB analysisDiagnosis yearMultivariable analysisPrediction of new brain metastases after radiosurgery: validation and analysis of performance of a multi-institutional nomogram
Ayala-Peacock DN, Attia A, Braunstein SE, Ahluwalia MS, Hepel J, Chung C, Contessa J, McTyre E, Peiffer AM, Lucas JT, Isom S, Pajewski NM, Kotecha R, Stavas MJ, Page BR, Kleinberg L, Shen C, Taylor RB, Onyeuku NE, Hyde AT, Gorovets D, Chao ST, Corso C, Ruiz J, Watabe K, Tatter SB, Zadeh G, Chiang VLS, Fiveash JB, Chan MD. Prediction of new brain metastases after radiosurgery: validation and analysis of performance of a multi-institutional nomogram. Journal Of Neuro-Oncology 2017, 135: 403-411. PMID: 28828698, PMCID: PMC5667906, DOI: 10.1007/s11060-017-2588-4.Peer-Reviewed Original ResearchConceptsDistant brain failureWhole brain radiotherapyNew brain metastasesBrain metastasesStereotactic radiosurgeryRisk of DBFEarly whole brain radiotherapyPrognostic modelUpfront whole brain radiotherapyMulti-institutional nomogramNumber of metastasesHigh-risk thresholdSRS monotherapyMargin doseBrain radiotherapyBrain failureContemporary cohortPrognostic indexMelanoma histologyRelative riskAcademic centersMetastasisPatientsValidation datasetAbsolute number
2016
A contemporary dose selection algorithm for stereotactic radiosurgery in the treatment of brain metastases - An initial report.
Colaco RJ, Yu JB, Bond JS, Bindra RS, Contessa JN, Knisely JPS, Chiang VL. A contemporary dose selection algorithm for stereotactic radiosurgery in the treatment of brain metastases - An initial report. Journal Of Radiosurgery And SBRT 2016, 4: 43-52. PMID: 29296425, PMCID: PMC5658834.Peer-Reviewed Original ResearchWhole brain radiotherapyDistant intracranial recurrenceLocal recurrenceBrain metastasesRTOG 90Overall local recurrence ratePrevious whole-brain radiotherapyProspective phase 2 trialWhole-brain radiation therapyBrain radiation therapyLocal recurrence rateMonths overall survivalPhase 2 trialRisk regression analysisGuideline dosesBrain radiotherapyPrimary endpointIntracranial recurrenceOverall survivalFine-GrayPrescription dosesRecurrence rateRetrospective outcomesMedical recordsLesion volume
2015
Equivalent whole brain dose for patients undergoing gamma knife for multiple lesions.
Jairam V, Chiang VL, Bond J, Yu JB. Equivalent whole brain dose for patients undergoing gamma knife for multiple lesions. Journal Of Radiosurgery And SBRT 2015, 3: 187-191. PMID: 29296401, PMCID: PMC5746333.Peer-Reviewed Original ResearchWhole-brain doseTotal tumor volumeMultiple lesionsTumor volumeBrain doseMedian total tumor volumeCumulative tumor volumeWhole brain dosesWhole brain radiotherapyTreatment of patientsBrain metastasesBrain radiotherapyIndividualized treatment planningTumor numberBrain dosesInstitutional databaseTumor locationMedian numberRadiosurgical treatmentPatientsRepresentative patientsLesionsEntire brainVital structuresGamma Knife