2022
The origins and molecular evolution of SARS-CoV-2 lineage B.1.1.7 in the UK
Hill V, Du Plessis L, Peacock T, Aggarwal D, Colquhoun R, Carabelli A, Ellaby N, Gallagher E, Groves N, Jackson B, McCrone J, O'Toole Á, Price A, Sanderson T, Scher E, Southgate J, Volz E, Barclay W, Barrett J, Chand M, Connor T, Goodfellow I, Gupta R, Harrison E, Loman N, Myers R, Robertson D, Pybus O, Rambaut A. The origins and molecular evolution of SARS-CoV-2 lineage B.1.1.7 in the UK. Virus Evolution 2022, 8: veac080. PMID: 36533153, PMCID: PMC9752794, DOI: 10.1093/ve/veac080.Peer-Reviewed Original ResearchEvolutionary ratesIncreased evolutionary rateVariant of concernNon-human animal populationsRate of evolutionLineage B.1.1.7SARS-CoV-2 lineagesSARS-CoV-2 lineage B.1.1.7Monophyletic cladeAncestral branchGenomic locationsPhylogenetic branchesMolecular evolutionMutational eventsGenomic surveillanceInfect immunocompetent hostsAlpha genomeSARS-CoV-2 variantsSARS-CoV-2Animal populationsSARS-CoV-2 variant of concernMutationsMutation profilesLineagesVariants
2021
Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic
Jackson B, Boni M, Bull M, Colleran A, Colquhoun R, Darby A, Haldenby S, Hill V, Lucaci A, McCrone J, Nicholls S, O’Toole Á, Pacchiarini N, Poplawski R, Scher E, Todd F, Webster H, Whitehead M, Wierzbicki C, Consortium T, Loman N, Connor T, Robertson D, Pybus O, Rambaut A. Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic. Cell 2021, 184: 5179-5188.e8. PMID: 34499854, PMCID: PMC8367733, DOI: 10.1016/j.cell.2021.08.014.Peer-Reviewed Original ResearchConceptsLocations of recombination breakpointsLineage-defining mutationsMultiple independent originsSets of mutationsSingle-nucleotide polymorphismsGenomic locationsInterlineage recombinationRecombination breakpointsParental virusRecombinant virusesB.1.1.7 variant of concernTransmission advantageGenomeVariant of concernSpike regionB.1.1.7 variantMutationsSequenced casesB.1.1.7VirusRecombinationSARS-CoV-2 virusTransmission clustersSARS-CoV-2Non-B.