2019
First in Human Experience with Direct Sodium Removal Using a Zero Sodium Peritoneal Solution
Rao V, Turner J, Mahoney D, Griffin M, Asher J, Ivey-Miranda J, Gomez N, Finkelstein F, Testani J. First in Human Experience with Direct Sodium Removal Using a Zero Sodium Peritoneal Solution. Journal Of Cardiac Failure 2019, 25: s7-s8. DOI: 10.1016/j.cardfail.2019.07.027.Peer-Reviewed Original ResearchStandard PD solutionHeart failurePeritoneal dialysisPD solutionsSignificant discomfortPeritoneal solutionsSodium removalHF animal modelsMethods 10 patientsSafety/tolerabilitySecondary efficacy endpointsPrimary endpointEfficacy endpointAdverse eventsBlood pressureSerum sodiumAlternative therapiesPeritoneal fluidPlasma glucosePlasma potassiumUltrafiltration volumeAnimal modelsIntraperitoneal volumeDSR groupVital signs
2018
Development of a Direct Peritoneal Sodium Removal Technique with Salt Free Solution
Mahoney D, Rao V, Asher J, Struyk G, Boutagy N, Feher A, Turner J, Sinusas A, Testani J. Development of a Direct Peritoneal Sodium Removal Technique with Salt Free Solution. Journal Of Cardiac Failure 2018, 24: s34. DOI: 10.1016/j.cardfail.2018.07.099.Peer-Reviewed Original ResearchPeritoneal dialysisIntraperitoneal volumeHeart failureHour dwellFluid removalPlasma volumeNon-renal routesPeritoneal fluid samplesSodium removalMinutes dwell timeSolute dragIndicator dilution techniquePD catheterSerial plasmaSerum sodiumArterial accessDwell timeFluid instillationAnesthetized pigsRemoval solutionPeritoneal solutionsSurgical implantationGrams of sodiumFluid volumeLonger dwell times