2020
First-in-Human Experience With Peritoneal Direct Sodium Removal Using a Zero-Sodium Solution
Rao VS, Turner JM, Griffin M, Mahoney D, Asher J, Jeon S, Yoo PS, Boutagy N, Feher A, Sinusas A, Wilson FP, Finkelstein F, Testani JM. First-in-Human Experience With Peritoneal Direct Sodium Removal Using a Zero-Sodium Solution. Circulation 2020, 141: 1043-1053. PMID: 31910658, PMCID: PMC7331276, DOI: 10.1161/circulationaha.119.043062.Peer-Reviewed Original ResearchConceptsStandard PD solutionExperimental heart failureHeart failurePD solutionsAdverse eventsPeritoneal dialysisSignificant discomfortSodium removalEnd-stage renal diseaseEnd pointElevated right atrial pressureMaintenance of euvolemiaPrimary end pointSecondary end pointsRight atrial pressureHuman proofLoss of responseSolute removalPorcine experimentsAtrial pressureRenal diseaseLoop diureticsSerum electrolytesHuman studiesPeritoneal membrane
2019
First in Human Experience with Direct Sodium Removal Using a Zero Sodium Peritoneal Solution
Rao V, Turner J, Mahoney D, Griffin M, Asher J, Ivey-Miranda J, Gomez N, Finkelstein F, Testani J. First in Human Experience with Direct Sodium Removal Using a Zero Sodium Peritoneal Solution. Journal Of Cardiac Failure 2019, 25: s7-s8. DOI: 10.1016/j.cardfail.2019.07.027.Peer-Reviewed Original ResearchStandard PD solutionHeart failurePeritoneal dialysisPD solutionsSignificant discomfortPeritoneal solutionsSodium removalHF animal modelsMethods 10 patientsSafety/tolerabilitySecondary efficacy endpointsPrimary endpointEfficacy endpointAdverse eventsBlood pressureSerum sodiumAlternative therapiesPeritoneal fluidPlasma glucosePlasma potassiumUltrafiltration volumeAnimal modelsIntraperitoneal volumeDSR groupVital signs
2018
Development of a Direct Peritoneal Sodium Removal Technique with Salt Free Solution
Mahoney D, Rao V, Asher J, Struyk G, Boutagy N, Feher A, Turner J, Sinusas A, Testani J. Development of a Direct Peritoneal Sodium Removal Technique with Salt Free Solution. Journal Of Cardiac Failure 2018, 24: s34. DOI: 10.1016/j.cardfail.2018.07.099.Peer-Reviewed Original ResearchPeritoneal dialysisIntraperitoneal volumeHeart failureHour dwellFluid removalPlasma volumeNon-renal routesPeritoneal fluid samplesSodium removalMinutes dwell timeSolute dragIndicator dilution techniquePD catheterSerial plasmaSerum sodiumArterial accessDwell timeFluid instillationAnesthetized pigsRemoval solutionPeritoneal solutionsSurgical implantationGrams of sodiumFluid volumeLonger dwell times