2022
Deletion of Jazf1 gene causes early growth retardation and insulin resistance in mice
Lee H, Jang H, Li H, Samuel V, Dudek K, Osipovich A, Magnuson M, Sklar J, Shulman G. Deletion of Jazf1 gene causes early growth retardation and insulin resistance in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2213628119. PMID: 36442127, PMCID: PMC9894197, DOI: 10.1073/pnas.2213628119.Peer-Reviewed Original ResearchConceptsKO miceEarly growth retardationInsulin resistanceFat massGrowth retardationAge-matched wild-type miceHepatic nuclear factor 4 alphaGH-IGF-1 axisHigh-fat diet feedingKO liversHyperinsulinemic-euglycemic clamp techniquePlasma growth hormone concentrationInsulin-like growth factor-1Type 2 diabetesGrowth hormone concentrationsIGF-1 expressionWild-type miceLean body massMuscle insulin resistanceGrowth factor-1Nuclear factor 4 alphaInsulin sensitivityDiet feedingPlasma concentrationsHormone concentrations
1992
Regulation of cell proliferation: Late down‐regulation of c‐myb preceding myelo‐monocytic cell differentiation
Yen A, Samuel V, Forbes M. Regulation of cell proliferation: Late down‐regulation of c‐myb preceding myelo‐monocytic cell differentiation. Journal Of Cellular Physiology 1992, 153: 147-156. PMID: 1522128, DOI: 10.1002/jcp.1041530119.Peer-Reviewed Original ResearchConceptsC-myb expressionC-Myb proteinC-MybNuclear oncogenesTerminal differentiationCell cycleCell differentiationC-MycTranscriptional regulatory activityCell proliferationDihydroxy vitamin D2Metabolic cascadeC-fosHL-60 cell differentiationTumor suppressor geneC-fos expressionPhenotypic differentiationDivision cycleHL-60 human promyelocytic leukemia cells