2018
Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-hydroxysteroid dehydrogenase type 1 transgenic mice
Abulizi A, Camporez JP, Zhang D, Samuel VT, Shulman GI, Vatner DF. Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-hydroxysteroid dehydrogenase type 1 transgenic mice. Metabolism 2018, 93: 1-9. PMID: 30576689, PMCID: PMC6401251, DOI: 10.1016/j.metabol.2018.12.003.Peer-Reviewed Original ResearchConceptsHepatic insulin resistanceEctopic lipid depositionInsulin resistanceHepatic lipid contentGlucocorticoid actionTransgenic miceLipid depositionSevere hepatic insulin resistanceTissue-specific insulin actionHepatic triglyceride contentHigh-fat dietHyperinsulinemic-euglycemic clampGlucocorticoid excessAkt serine phosphorylationGlucocorticoid activityHepatic steatosisFat dietLittermate controlsHepatic insulinInsulin actionTriglyceride contentPKCε activationDevelopment of lipidLipid contentMice
2012
Mechanisms for Insulin Resistance: Common Threads and Missing Links
Samuel VT, Shulman GI. Mechanisms for Insulin Resistance: Common Threads and Missing Links. Cell 2012, 148: 852-871. PMID: 22385956, PMCID: PMC3294420, DOI: 10.1016/j.cell.2012.02.017.Peer-Reviewed Original ResearchConceptsUnfolded protein response pathwayProtein response pathwayInsulin resistanceFatty acid uptakeResponse pathwaysLipid metabolitesAcid uptakeSpecific lipid metabolitesEctopic lipid depositionImmune pathwaysPathwayImpaired insulinCommon final pathwayCellular changesComplex metabolic disorderSkeletal muscleMetabolic disordersLipid depositionFinal pathwayEnergy expenditureAccumulationEtiological pathwaysMetabolitesMissing linkResistance