Predictors, Presentation, and Treatment Outcomes of Recurrent Hepatocellular Carcinoma After Liver Transplantation: A Large Single Center Experience
Ekpanyapong S, Philips N, Loza BL, Abt P, Furth EE, Tondon R, Khungar V, Olthoff K, Shaked A, Hoteit MA, Reddy KR. Predictors, Presentation, and Treatment Outcomes of Recurrent Hepatocellular Carcinoma After Liver Transplantation: A Large Single Center Experience. Journal Of Clinical And Experimental Hepatology 2019, 10: 304-315. PMID: 32655233, PMCID: PMC7335705, DOI: 10.1016/j.jceh.2019.11.003.Peer-Reviewed Original ResearchRecurrent hepatocellular carcinomaLiver transplantationHepatocellular carcinomaHCC recurrenceHCC recurrence post-LTPost-LT HCC recurrenceLarge single-center experienceAccepted therapeutic optionRecurrence post-LTSirolimus-based immunosuppressionSingle-center experiencePredictors of recurrencePredictors of survivalMultiple recurrent lesionsExplant pathologyPost-LTPeritoneal diseasePeritoneal recurrenceInitial recurrenceMedian survivalCenter experienceLow albuminCareful candidate selectionClinical presentationMedian timeTacrolimus and Indomethacin Are Safe and Effective at Reducing Pancreatitis After Endoscopic Retrograde Cholangiopancreatography in Patients Who Have Undergone Liver Transplantation
Thiruvengadam NR, Forde KA, Chandrasekhara V, Ahmad NA, Ginsberg GG, Khungar V, Kochman ML. Tacrolimus and Indomethacin Are Safe and Effective at Reducing Pancreatitis After Endoscopic Retrograde Cholangiopancreatography in Patients Who Have Undergone Liver Transplantation. Clinical Gastroenterology And Hepatology 2019, 18: 1224-1232.e1. PMID: 31622734, DOI: 10.1016/j.cgh.2019.10.014.Peer-Reviewed Original ResearchConceptsEndoscopic retrograde cholangiopancreatographyRisk of PEPDevelopment of PEPLiver transplantationTrough levelsBiliary complicationsIndomethacin useRectal indomethacinRetrospective studyRetrograde cholangiopancreatographyERCP proceduresOdds ratioMixed-effects multivariable logistic regressionEffectiveness of tacrolimusIncidence of PEPTacrolimus trough levelsCommon adverse eventsChronic kidney diseaseGlomerular filtration rateMultivariable logistic regressionRate of pancreatitisAddition of indomethacinChronic rejectionSevere PEPStable doseAn Advanced Practice Practitioner–Based Program to Reduce 30‐ and 90‐Day Readmissions After Liver Transplantation
Mahmud N, Halpern S, Farrell R, Ventura K, Thomasson A, Lewis H, Olthoff KM, Levine MH, Nazarian S, Khungar V. An Advanced Practice Practitioner–Based Program to Reduce 30‐ and 90‐Day Readmissions After Liver Transplantation. Liver Transplantation 2019, 25: 901-910. PMID: 30947393, PMCID: PMC6548546, DOI: 10.1002/lt.25466.Peer-Reviewed Original ResearchMeSH KeywordsAgedEnd Stage Liver DiseaseFemaleHumansLiver TransplantationMaleMiddle AgedNurse PractitionersPatient ReadmissionPilot ProjectsPostoperative CarePostoperative ComplicationsProfessional RoleProgram EvaluationRetrospective StudiesRisk FactorsSex FactorsTime FactorsTreatment OutcomeUnited StatesConceptsLiver transplantationReadmission ratesRisk factorsPostexposure groupCare programIndex hospitalization characteristicsRetrospective cohort studyRisk of readmissionHigher readmission ratesAssociated risk factorsAdvanced practice practitionersIndex hospitalizationAnalytic cohortCohort studyHospitalization characteristicsReferral centerHospital readmissionLT centersAdjusted analysisMale sexNurse practitionersReadmissionClinic availabilitySignificant differencesPatients