2010
Genome-wide analysis of germ cell proliferation in C . elegans identifies VRK-1 as a key regulator of CEP-1/p53
Waters K, Yang AZ, Reinke V. Genome-wide analysis of germ cell proliferation in C . elegans identifies VRK-1 as a key regulator of CEP-1/p53. Developmental Biology 2010, 344: 1011-1025. PMID: 20599896, PMCID: PMC3375680, DOI: 10.1016/j.ydbio.2010.06.022.Peer-Reviewed Original ResearchConceptsGerm cell proliferationVRK-1Germ cellsCEP-1CEP-1/p53Cell proliferationImportant regulatory relationshipsGenome-wide analysisGene expression profilingGermline proliferationCell cycle arrestUseful model systemC. elegansProliferation defectFunctional characterizationNegative regulationExpression profilingRegulatory relationshipsKey regulatorP53 activityCycle arrestUnsuspected mechanismElegansModel systemProliferation
2006
Regulation of developmental rate and germ cell proliferation in Caenorhabditis elegans by the p53 gene network
Derry W, Bierings R, van Iersel M, Satkunendran T, Reinke V, Rothman J. Regulation of developmental rate and germ cell proliferation in Caenorhabditis elegans by the p53 gene network. Cell Death & Differentiation 2006, 14: 662-670. PMID: 17186023, DOI: 10.1038/sj.cdd.4402075.Peer-Reviewed Original ResearchConceptsCEP-1Genotoxic stressP53 family membersComplex transcriptional regulatory networksDevelopmental rateTranscriptional regulatory networksCell proliferationP53-binding siteGerm cell proliferationTumor suppressor p53Absence of stressGermline apoptosisCaenorhabditis elegansTranscriptional networksC. elegansMammalian counterpartsCheckpoint responseGene networksRegulatory networksTranscriptional targetsP53 gene networkEmbryonic viabilityHuman p63Negative regulatorP53 family