2015
Superantigens produced by catheter-associated Staphylococcus aureus elicit systemic inflammatory disease in the absence of bacteremia
Chung J, Greenwood-Quaintance K, Karau MJ, Tilahun A, Khaleghi SR, Chowdhary VR, David CS, Patel R, Rajagopalan G. Superantigens produced by catheter-associated Staphylococcus aureus elicit systemic inflammatory disease in the absence of bacteremia. Journal Of Leukocyte Biology 2015, 98: 271-281. PMID: 25979434, PMCID: PMC4501677, DOI: 10.1189/jlb.4a1214-577rr.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCatheter-Related InfectionsCatheters, IndwellingCD4-Positive T-LymphocytesEnterotoxinsGene DeletionHistocompatibility AntigensHumansKidneyLiverLungLymphocyte ActivationMiceMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaSpleenStaphylococcal InfectionsStaphylococcus aureusSuperantigensConceptsS. aureusHLA-DR3 transgenic miceLong intravenous catheterSystemic immune activationSerum cytokine levelsSystemic inflammatory diseaseAbsence of bacteremiaMHC class II moleculesInvasive staphylococcal diseaseToxigenic S. aureusClinical S. aureus isolatesS. aureus isolatesClass II moleculesIsogenic S. aureusCytokine levelsHLA-DR3Immune activationInflammatory diseasesIntravenous cathetersStaphylococcal diseaseRole of SAgsDevice-associated infectionsT cellsClinical consequencesForeign body
2007
Characterization of haemorrhagic pulmonary capillaritis: another manifestation of Pristane-induced lupus
Chowdhary V, Grande J, Luthra H, David C. Characterization of haemorrhagic pulmonary capillaritis: another manifestation of Pristane-induced lupus. Rheumatology 2007, 46: 1405-1410. PMID: 17576695, DOI: 10.1093/rheumatology/kem117.Peer-Reviewed Original ResearchConceptsAnti-neutrophil cytoplasm antibodiesBronchoalveolar lavagePulmonary capillaritisAntinuclear antibodiesIL-10IL-6IL-4IL-2TNF-alphaIFN-gammaPhosphate-buffered saline injectionEvidence of vasculitisLupus-specific autoantibodiesPristane-induced lupusPristane-injected miceImmune complex depositionSingle intraperitoneal injectionDifferential cell countsPristane injectionAlveolar inflammationCytokine levelsCytoplasm antibodiesLupus lesionsNeutrophil infiltrationEndothelial injury