2015
Obstructive Sleep Apnea: A New Preventive and Therapeutic Target for Stroke A New Kid on the Block
Mohsenin V. Obstructive Sleep Apnea: A New Preventive and Therapeutic Target for Stroke A New Kid on the Block. The American Journal Of Medicine 2015, 128: 811-816. PMID: 25731137, DOI: 10.1016/j.amjmed.2015.01.037.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaRisk factorsPersistent neurologic impairmentStroke-related outcomesGood neurologic outcomePresence of hypertensionMajority of patientsRisk of strokeTraditional risk factorsCommon comorbid conditionsCause of deathNeurologic outcomeNeurologic recoverySecondary preventionComorbid conditionsNeurologic impairmentAtrial fibrillationDiagnostic workupEarly recognitionStroke rateApneaTherapeutic targetHealthcare providersStroke
2006
Chronic obstructive pulmonary disease and sleep: the interaction.
Urbano F, Mohsenin V. Chronic obstructive pulmonary disease and sleep: the interaction. Panminerva Medica 2006, 48: 223-30. PMID: 17215794.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseasePulmonary diseaseSevere chronic obstructive pulmonary diseaseRespiratory muscle fatigueRight ventricular overloadElevated pulmonary pressuresUpper airway resistanceFourth leading causeFunctional residual capacityGoal of therapyOxyhemoglobin dissociation curveProfound adverse effectsMillion adultsResultant hypoxemiaOxygen desaturationPulmonary rehabilitationPulmonary pressureVentricular overloadAirway resistanceRespiratory driveSmoking cessationMorning fatigueLung mechanicsSleep disturbances
2001
Sleep-Related Breathing Disorders and Risk of Stroke
Mohsenin V. Sleep-Related Breathing Disorders and Risk of Stroke. Stroke 2001, 32: 1271-1278. PMID: 11387486, DOI: 10.1161/01.str.32.6.1271.Peer-Reviewed Original ResearchConceptsSleep-related breathing disordersTransient ischemic attackRisk of strokeBreathing disordersRisk factorsSleep apnea disorderIschemic attackApnea disorderHematologic changesHigh prevalenceNormal sleep stateModifiable risk factorsPresence of hypertensionRecent large epidemiological studiesPossible pathogenetic mechanismsLarge epidemiological studiesDiurnal hypertensionCerebral perfusionSignificant morbidityCerebral hemodynamicsPathogenetic mechanismsEpidemiological studiesStrokeHypertensionPatients