Genetic contribution to microglial activation in schizophrenia
Koskuvi M, Pörsti E, Hewitt T, Räsänen N, Wu Y, Trontti K, McQuade A, Kalyanaraman S, Ojansuu I, Vaurio O, Cannon T, Lönnqvist J, Therman S, Suvisaari J, Kaprio J, Blurton-Jones M, Hovatta I, Lähteenvuo M, Rolova T, Lehtonen Š, Tiihonen J, Koistinaho J. Genetic contribution to microglial activation in schizophrenia. Molecular Psychiatry 2024, 1-12. PMID: 38519640, DOI: 10.1038/s41380-024-02529-1.Peer-Reviewed Original ResearchIngenuity Pathway AnalysisGene OntologyMajor histocompatibility complexAffected twinHuman induced pluripotent stem cell-derived microgliaExtracellular matrix signalingUpregulation of major histocompatibility complexHealthy individualsIncreased expression of inflammatory genesIncreased expressionMicroglial activationResponse to clozapineStem cell-derived microgliaBrain-resident immune cellsResponse to interleukin-1 betaPathophysiology of schizophreniaInvolvement of neuroinflammatory processesResident immune cellsExpression of inflammatory genesIncreased microglial activationInterleukin-1 betaAberrant activation of microgliaHuman cell modelsRNA sequencingInvading pathogens