Tyler Rice, PhD
Postdoctoral Fellow in Pediatrics (Neonatology)About
Titles
Postdoctoral Fellow in Pediatrics (Neonatology)
Biography
RESEARCH DESCRIPTION:
The human immune system is a complex hierarchy of tissues, cells, and genetic programs that respond to diverse endogenous and environmental stimuli. While previously thought to be immature in utero, the fetal immune system is now known to be surprisingly active during the earliest stages of life, exhibiting signs of activation and immune memory as early as the second trimester of pregnancy. However, the basis of this activated fetal immune state remains unclear. In the Konnikova lab, we are interested in pursuing research that addresses numerous questions with wide-ranging implications for pregnant mothers, newborn babies, and far into adulthood, such as:
Does fetal immune activation lead to adverse outcomes like preterm birth?
Are fetal immune cells specifically reactive to bacterial or viral antigens?
What maternal factors influence fetal immune development?
What are the key metrics of immune health in utero and in early life?
BIO:
Tyler pursued scientific research from a young age. His academic training took him to Auburn University's Samuel Ginn College of Engineering, the National Institute of Allergy and Infectious Diseases (NIAID), and Yale Department of Immunobiology. His research interests include mucosal immunology, host-microbe interactions, and fetal immune development. Tyler enjoys building community, mentoring young people, reading and writing poetry, and exploring natural spaces with his dog. He welcomes conversations of all kinds and is deeply curious about the callings that lead people into their life's work.
Education & Training
- PhD
- Yale University, Immunobiology (2021)
- Non Degree Program
- NIAID, Laboratory of Allergic Diseases, Postbac Intramural Research Training Award (2015)
- BS
- Auburn University (2013)
Research
Overview
Medical Subject Headings (MeSH)
- View Lab Website
Konnikova Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Noah Wolcott Palm, PhD
Anjelica Martin, BS, RLATG
Deguang Song
Mytien Nguyen
David van Dijk, PhD, MSc, BSc
Esen Sefik
Bacteria
Autoimmunity
Publications
2024
A host–microbiota interactome reveals extensive transkingdom connectivity
Sonnert N, Rosen C, Ghazi A, Franzosa E, Duncan-Lowey B, González-Hernández J, Huck J, Yang Y, Dai Y, Rice T, Nguyen M, Song D, Cao Y, Martin A, Bielecka A, Fischer S, Guan C, Oh J, Huttenhower C, Ring A, Palm N. A host–microbiota interactome reveals extensive transkingdom connectivity. Nature 2024, 628: 171-179. PMID: 38509360, DOI: 10.1038/s41586-024-07162-0.Peer-Reviewed Original ResearchCitationsAltmetricConceptsNiche colonizationHost–microorganism interactionsHost-microbiota interactionsInvade host tissuesStrain-specific interactionsHost cells in vitroConspecific strainsEffect of indigenous microorganismsHost biologyHost proteinsSecreted proteinsCommensal microorganismsExoproteinsBacterial strainsDiverse phylogenyMolecular basisMyriad microorganismsTissue of originTissue isolationCells in vitroInteractomeBinding patternsHost tissuesBiological logicHost immune system in vivo
2022
Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites
Cao Y, Oh J, Xue M, Huh WJ, Wang J, Gonzalez-Hernandez JA, Rice TA, Martin AL, Song D, Crawford JM, Herzon SB, Palm NW. Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites. Science 2022, 378: eabm3233. PMID: 36302024, PMCID: PMC9993714, DOI: 10.1126/science.abm3233.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsColorectal cancerInflammatory bowel disease patientsBowel disease patientsInflammatory bowel diseaseIndigenous gut microbesBowel diseaseDisease patientsCommensal microbiotaDNA damageColon tumorigenesisElicit DNA damageGut microbesGenotoxic metabolitesGut commensalsMorganella morganiiPatientsGenotoxic chemicalsDiseaseMicrobiotaMetabolitesGenotoxicityCancerMiceFull spectrumDamageInterspecies commensal interactions have nonlinear impacts on host immunity
Rice TA, Bielecka AA, Nguyen MT, Rosen CE, Song D, Sonnert ND, Yang Y, Cao Y, Khetrapal V, Catanzaro JR, Martin AL, Rashed SA, Leopold SR, Hao L, Yu X, van Dijk D, Ring AM, Flavell RA, de Zoete MR, Palm NW. Interspecies commensal interactions have nonlinear impacts on host immunity. Cell Host & Microbe 2022, 30: 988-1002.e6. PMID: 35640610, PMCID: PMC9283318, DOI: 10.1016/j.chom.2022.05.004.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsImmunological outcomesCell activationIntestinal epithelial cell activationInflammatory bowel disease patientsBowel disease patientsDendritic cell activationMesenteric lymph nodesSystemic antibody responsesEpithelial cell activationImmunological milieuLymph nodesAntibody responseDisease patientsAkkermansia muciniphilaGnotobiotic miceHost immunityCommensal microbesHuman cohortsHuman gut bacteriaGut bacteriaMiceAllobaculumMuciniphilaDiseaseIncomplete penetrance
2020
Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition
Chen JW, Rice TA, Bannock JM, Bielecka AA, Strauss JD, Catanzaro JR, Wang H, Menard LC, Anolik JH, Palm NW, Meffre E. Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition. Science 2020, 369: 320-325. PMID: 32675374, DOI: 10.1126/science.aay9733.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsB cell toleranceB cellsCell toleranceEarly human fetal lifeHuman fetal B cellsPolyreactive B cellsHuman fetal lifeApoptotic cellsFetal B cellsHuman fetal liverB cell specificitySingle B cellsAbundant autoantibodiesGut microbiota assemblyNewborn seraFetal lifeBone marrowFetal developmentHealthy adultsCommensal bacteriaRepertoire breadthMicrobiota assemblyFetal liverPreimmune repertoireCell specificityEnteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity
Jarret A, Jackson R, Duizer C, Healy ME, Zhao J, Rone JM, Bielecki P, Sefik E, Roulis M, Rice T, Sivanathan KN, Zhou T, Solis AG, Honcharova-Biletska H, Vélez K, Hartner S, Low JS, Qu R, de Zoete MR, Palm NW, Ring AM, Weber A, Moor AE, Kluger Y, Nowarski R, Flavell RA. Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity. Cell 2020, 180: 50-63.e12. PMID: 31923399, PMCID: PMC7339937, DOI: 10.1016/j.cell.2019.12.016.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEnteric nervous systemSingle-cell sequencingMucosal barrier immunitySingle-molecule fluorescenceIL-18Non-redundant roleSitu mRNA hybridization studiesEpithelial cellsUnbiased RNA sequencingRNA sequencingProtein responseBarrier immunityNervous systemConfocal microscopyCytokine IL-18Hybridization studiesInvasive bacterial infectionsSalmonella typhimurium infectionSequencingProfound consequencesIntestinal neuronsEnteric neuronsIntestinal immunityMucosal barrierTyphimurium infection
2016
Signaling via pattern recognition receptors NOD2 and TLR2 contributes to immunomodulatory control of lethal pneumovirus infection.
Rice TA, Brenner TA, Percopo CM, Ma M, Keicher JD, Domachowske JB, Rosenberg HF. Signaling via pattern recognition receptors NOD2 and TLR2 contributes to immunomodulatory control of lethal pneumovirus infection. Antiviral Res 2016, 132: 131-40. PMID: 27312104, DOI: 10.1016/j.antiviral.2016.06.002.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
honor Hartwell Fellowship
National AwardThe Hartwell FoundationDetails11/01/2024honor Multidisciplinary Postdoctoral Training Award
Yale School of Medicine AwardYale Center for Clinical Investigation (YCCI)Details06/01/2023