Identification of Novel Interactions in HIV-1 Capsid Protein Assembly by High-resolution Mass Spectrometry
Lanman J, Lam TT, Barnes S, Sakalian M, Emmett MR, Marshall AG, Prevelige PE. Identification of Novel Interactions in HIV-1 Capsid Protein Assembly by High-resolution Mass Spectrometry. Journal Of Molecular Biology 2003, 325: 759-772. PMID: 12507478, DOI: 10.1016/s0022-2836(02)01245-7.Peer-Reviewed Original ResearchConceptsHigh-resolution mass spectrometryMass spectrometryHIV-1 capsid protein assembliesCapsid protein assemblySupramolecular structuresMature HIV-1 virionsHydrogen exchange protection factorsProtein assembliesChemical crosslinking experimentsCA tubesSpectrometryIntersubunit interactionsProtection factorSubunit interfaceC domain interactionsInteractionStructureSoluble capsid proteinAssemblyCryo-electron microscopy image reconstruction