Preincubation With Everolimus and Sirolimus Reduces Organic Anion-Transporting Polypeptide (OATP)1B1- and 1B3-Mediated Transport Independently of mTOR Kinase Inhibition: Implication in Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions
Farasyn T, Crowe A, Hatley O, Neuhoff S, Alam K, Kanyo J, Lam T, Ding K, Yue W. Preincubation With Everolimus and Sirolimus Reduces Organic Anion-Transporting Polypeptide (OATP)1B1- and 1B3-Mediated Transport Independently of mTOR Kinase Inhibition: Implication in Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions. Journal Of Pharmaceutical Sciences 2019, 108: 3443-3456. PMID: 31047942, PMCID: PMC6759397, DOI: 10.1016/j.xphs.2019.04.019.Peer-Reviewed Original ResearchBiological TransportCell LineDrug InteractionsEverolimusHEK293 CellsHumansLiver-Specific Organic Anion Transporter 1SirolimusSolute Carrier Organic Anion Transporter Family Member 1B3TOR Serine-Threonine Kinases