2020
Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea
Ahsan MK, Figueroa-Hall L, Baratta V, Garcia-Milian R, Lam TT, Hoque K, Salas PJ, Ameen NA. Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea. AJP Gastrointestinal And Liver Physiology 2020, 319: g121-g132. PMID: 32567324, PMCID: PMC7500270, DOI: 10.1152/ajpgi.00076.2020.Peer-Reviewed Original Research14-3-3 ProteinsAnimalsBacterial ToxinsCystic Fibrosis Transmembrane Conductance RegulatorDexamethasoneDiarrheaDimethyl SulfoxideEnterotoxinsEscherichia coli ProteinsGene Expression RegulationImmediate-Early ProteinsMaleNedd4 Ubiquitin Protein LigasesPhosphatidylinositol 3-KinasesProtein Serine-Threonine KinasesProtein TransportProto-Oncogene Proteins c-aktPyruvate Dehydrogenase Acetyl-Transferring KinaseRatsRats, Sprague-DawleySodium-Hydrogen Exchanger 3
2009
Diversification of a Salmonella Virulence Protein Function by Ubiquitin-Dependent Differential Localization
Patel JC, Hueffer K, Lam TT, Galán JE. Diversification of a Salmonella Virulence Protein Function by Ubiquitin-Dependent Differential Localization. Cell 2009, 137: 283-294. PMID: 19379694, PMCID: PMC2673707, DOI: 10.1016/j.cell.2009.01.056.Peer-Reviewed Original ResearchMeSH KeywordsActinsBacterial ProteinsHost-Pathogen InteractionsHumansPinocytosisProto-Oncogene Proteins c-aktSalmonella InfectionsSalmonella typhimuriumUbiquitinConceptsEffector proteinsCellular functionsType III secretion systemBacterial effector proteinsUbiquitin-dependent mannerDifferent cellular compartmentsHost cellular machinerySame enzymatic activityVesicular traffickingCellular machineryProtein functionSecretion systemCellular compartmentsBacterial internalizationFunctional repertoirePlasma membraneRegulated mannerAkt activationHost cellsDifferential localizationBacterial replicationVirulence factorsEnzymatic activityBacterial pathogensProtein