2017
The repeat region of cortactin is intrinsically disordered in solution
Li X, Tao Y, Murphy JW, Scherer AN, Lam TT, Marshall AG, Koleske AJ, Boggon TJ. The repeat region of cortactin is intrinsically disordered in solution. Scientific Reports 2017, 7: 16696. PMID: 29196701, PMCID: PMC5711941, DOI: 10.1038/s41598-017-16959-1.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceCircular DichroismCortactinDeuterium Exchange MeasurementMass SpectrometryProtein Conformation, alpha-HelicalProtein UnfoldingScattering, Small AngleX-Ray DiffractionConceptsCortactin repeatsRepeat regionActin filamentsHydrogen-deuterium exchange mass spectrometryAdjacent helical regionsMulti-domain proteinsExchange mass spectrometryExtensive biophysical analysisCircular dichroismHydrophobic core regionSmall-angle X-ray scatteringBiophysical analysisHelical regionCortactinRepeatsSimilar copiesUnfolded peptidesProteinMotifSize exclusion chromatographyMass spectrometryFilamentsExclusion chromatographyX-ray scatteringRegion
2005
Functional visualization of viral molecular motor by hydrogen-deuterium exchange reveals transient states
Lísal J, Lam TT, Kainov DE, Emmett MR, Marshall AG, Tuma R. Functional visualization of viral molecular motor by hydrogen-deuterium exchange reveals transient states. Nature Structural & Molecular Biology 2005, 12: 460-466. PMID: 15834422, DOI: 10.1038/nsmb927.Peer-Reviewed Original Research