2001
Ibotenate Injections into the Pre‐ and Parasubiculum Provide Partial Protection against Kainate‐Induced Epileptic Damage in Layer III of Rat Entorhinal Cortex
Eid T, Du F, Schwarcz R. Ibotenate Injections into the Pre‐ and Parasubiculum Provide Partial Protection against Kainate‐Induced Epileptic Damage in Layer III of Rat Entorhinal Cortex. Epilepsia 2001, 42: 817-824. PMID: 11488878, DOI: 10.1046/j.1528-1157.2001.042007817.x.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyEntorhinal cortexLayer IIIIbotenate injectionLobe epilepsySeizure-induced damageLoss of neuronsLayer III neuronsRat entorhinal cortexEpileptic damagePartial neuroprotectionExcitatory afferentsPrimary lesionSeizure activityEntorhinal neuronsAnimal modelsIbotenate lesionsPartial protectionLesionsNeuronsKainatePresubiculumEpilepsySerial reconstructionCortex
1995
Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy
Du F, Eid T, Lothman E, Kohler C, Schwarcz R. Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy. Journal Of Neuroscience 1995, 15: 6301-6313. PMID: 7472396, PMCID: PMC6577998, DOI: 10.1523/jneurosci.15-10-06301.1995.Peer-Reviewed Original ResearchConceptsPreferential neuronal lossTemporal lobe epilepsyNeuronal lossMedial entorhinal cortexEntorhinal cortexLayer IIILobe epilepsyRat modelIntractable temporal lobe epilepsyAcute status epilepticusLithium/pilocarpineParvalbumin-positive neuronsIntracellular calcium ion concentrationKainic acid administrationNerve cell lossAdult male ratsInjection of diazepamSurviving neuronsProlonged seizuresStatus epilepticusAcid administrationNissl stainingVentral hippocampusKainic acidPathological elevation