2001
Disruption of Inhibition in Area CA1 of the Hippocampus in a Rat Model of Temporal Lobe Epilepsy
Denslow M, Eid T, Du F, Schwarcz R, Lothman E, Steward O. Disruption of Inhibition in Area CA1 of the Hippocampus in a Rat Model of Temporal Lobe Epilepsy. Journal Of Neurophysiology 2001, 86: 2231-2245. PMID: 11698514, DOI: 10.1152/jn.2001.86.5.2231.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyLayer III neuronsPaired-pulse stimulationEntorhinal cortexCommissural projectionsDisruption of inhibitionHeterosynaptic inhibitionAOAA injectionPopulation spikesLobe epilepsyInhibitory functionDentate gyrusRat modelAminooxyacetic acidInhibitory interneuronsControl animalsElectrolytic lesionsTemporo-ammonic pathwayMultiple population spikesPaired-pulse inhibitionDuration of afterdischargeLoss of neuronsHigh-frequency stimulationNumber of stimulationsAbnormal physiological responses
1995
Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy
Du F, Eid T, Lothman E, Kohler C, Schwarcz R. Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy. Journal Of Neuroscience 1995, 15: 6301-6313. PMID: 7472396, PMCID: PMC6577998, DOI: 10.1523/jneurosci.15-10-06301.1995.Peer-Reviewed Original ResearchConceptsPreferential neuronal lossTemporal lobe epilepsyNeuronal lossMedial entorhinal cortexEntorhinal cortexLayer IIILobe epilepsyRat modelIntractable temporal lobe epilepsyAcute status epilepticusLithium/pilocarpineParvalbumin-positive neuronsIntracellular calcium ion concentrationKainic acid administrationNerve cell lossAdult male ratsInjection of diazepamSurviving neuronsProlonged seizuresStatus epilepticusAcid administrationNissl stainingVentral hippocampusKainic acidPathological elevation