2021
Network-Related Changes in Neurotransmitters and Seizure Propagation During Rodent Epileptogenesis
Dhaher R, Gruenbaum SE, Sandhu MRS, Ottestad-Hansen S, Tu N, Wang Y, Lee TW, Deshpande K, Spencer DD, Danbolt NC, Zaveri HP, Eid T. Network-Related Changes in Neurotransmitters and Seizure Propagation During Rodent Epileptogenesis. Neurology 2021, 96: e2261-e2271. PMID: 33722994, PMCID: PMC8166437, DOI: 10.1212/wnl.0000000000011846.Peer-Reviewed Original ResearchConceptsSpontaneous seizuresSeizure propagationSeizure focusMesial temporal lobe epilepsyExtracellular brain levelsTemporal lobe epilepsyExtracellular glutamate levelsRelevant rodent modelsGlutamine synthetase inhibitor methionine sulfoximineTransporter subtype 1Contralateral hippocampusLobe epilepsyBrain levelsBrain microdialysisExtracellular GABANeurotransmitter levelsSeizure initiationGlutamate levelsSeizure onsetEpilepsy networkRodent modelsSubtype 1EpileptogenesisHippocampusBrain regions
2020
Gene expression in the epileptic (EL) mouse hippocampus
Lee TS, Li AY, Rapuano A, Mantis J, Eid T, Seyfried TN, de Lanerolle NC. Gene expression in the epileptic (EL) mouse hippocampus. Neurobiology Of Disease 2020, 147: 105152. PMID: 33153970, DOI: 10.1016/j.nbd.2020.105152.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyHuman temporal lobe epilepsySeizure focusHippocampal seizure focusRole of neurogliaExtensive neuronal lossMolecular changesEpileptic miceMicroglial activationNeuronal lossNeuron lossEl miceLobe epilepsySeizure modelHippocampal fieldsSeizure generationPathological changesPaucity of studiesMouse hippocampusAnimal modelsHeat shock proteinsNormal populationPathological processesExpression levelsEpilepsy
2006
Changes in glial glutamate transporters in human epileptogenic hippocampus: Inadequate explanation for high extracellular glutamate during seizures
Bjørnsen LP, Eid T, Holmseth S, Danbolt NC, Spencer DD, de Lanerolle NC. Changes in glial glutamate transporters in human epileptogenic hippocampus: Inadequate explanation for high extracellular glutamate during seizures. Neurobiology Of Disease 2006, 25: 319-330. PMID: 17112731, DOI: 10.1016/j.nbd.2006.09.014.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmino Acid Transport System X-AGAstrocytesChildChild, PreschoolDown-RegulationEpilepsyEpilepsy, Temporal LobeExcitatory Amino Acid Transporter 1Excitatory Amino Acid Transporter 2Extracellular FluidFemaleGlutamic AcidHippocampusHumansImmunohistochemistryMaleMicroscopy, Electron, TransmissionMiddle AgedUp-RegulationConceptsTemporal lobe epilepsySclerotic hippocampusNeuronal lossExtracellular glutamateGlial glutamate transporters GLASTHigh extracellular glutamate levelsGroups of hippocampiHuman epileptogenic hippocampusLess neuronal lossExtracellular glutamate levelsGlutamate transporter GLASTGlial glutamate transportersVivo dialysis studyHigh extracellular glutamateSuch compensatory changesEpileptogenic hippocampusHippocampal sclerosisLobe epilepsySclerotic groupSeizure focusGlutamate levelsWeak immunoreactivityGLT-1Glutamate transportersHippocampus
1998
Glutamate receptor subunits GluR1 and GluR2/3 distribution shows reorganization in the human epileptogenic hippocampus
De Lanerolle N, Eid T, Von Campe G, Kovacs I, Spencer D, Brines M. Glutamate receptor subunits GluR1 and GluR2/3 distribution shows reorganization in the human epileptogenic hippocampus. European Journal Of Neuroscience 1998, 10: 1687-1703. PMID: 9751141, DOI: 10.1046/j.1460-9568.1998.00171.x.Peer-Reviewed Original ResearchConceptsDentate granule cellsEpileptogenic hippocampusProximal dendritesGranule cellsGlutamate receptor subunits GluR1Human epileptogenic hippocampusControl of seizuresCA3 pyramidal neuronsTemporal lobe epilepsyDendrites of neuronsSitu hybridization histochemistrySubunit-specific antibodiesGluR1 immunoreactivitySame hippocampusFlop splice variantsHilar neuronsGlutamatergic responsesNeuronal lossLobe epilepsyPyramidal neuronsPrincipal neuronsSeizure focusSubunit GluR1Ammon's hornDendritic excrescences