2021
Altered hippocampal astroglial metabolism is associated with aging and preserved spatial learning and memory
Ebersole J, Rose G, Eid T, Behar K, Patrylo P. Altered hippocampal astroglial metabolism is associated with aging and preserved spatial learning and memory. Neurobiology Of Aging 2021, 102: 188-199. PMID: 33774381, DOI: 10.1016/j.neurobiolaging.2021.02.015.Peer-Reviewed Original ResearchConceptsArtificial cerebrospinal fluidAstroglial metabolismNeural metabolismHippocampus-dependent cognitive functionGlutamate-glutamine cyclingFischer 344 ratsHippocampus-dependent learningAge-related decreaseAU ratsCognitive functionLiquid chromatography-tandem mass spectroscopyGlutamatergic neurotransmissionCognitive declineHippocampal slicesSpatial learningCognitive statusHippocampal subregionsCerebrospinal fluidImpaired ratsMetabolism correlateYoung adultsCompensatory changesRatsC-glucoseMemory
2017
2092
Gruenbaum S, Dhaher R, Rapuano A, Eid T. 2092. Journal Of Clinical And Translational Science 2017, 1: 56-56. PMCID: PMC6798929, DOI: 10.1017/cts.2017.200.Peer-Reviewed Original ResearchTemporal lobe epilepsyDays of drinkingDentate hilusBCAA groupNeuronal viabilityControl groupHilar neuron lossHilar neuronal lossRight dentate gyrusRelevant rodent modelsRole of BCAABCAA ingestionNeuronal lossSpontaneous seizuresLobe epilepsyNeuron lossSeizure activityChronic ingestionDentate gyrusInfusion siteHilar regionRodent modelsMethionine sulfoximineNeurochemical modulationRats
2013
A Cool Intervention for Posttraumatic Epilepsy
Eid T. A Cool Intervention for Posttraumatic Epilepsy. Science Translational Medicine 2013, 5 DOI: 10.1126/scitranslmed.3006347.Peer-Reviewed Original Research
2008
Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats
Eid T, Ghosh A, Wang Y, Beckström H, Zaveri HP, Lee TS, Lai JC, Malthankar-Phatak GH, de Lanerolle NC. Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats. Brain 2008, 131: 2061-2070. PMID: 18669513, PMCID: PMC2724901, DOI: 10.1093/brain/awn133.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyMesial temporal sclerosisRecurrent seizuresTemporal sclerosisBrain pathologyIntractable mesial temporal lobe epilepsyTemporal lobe epilepsyGlutamine synthetase deficiencyNovel animal modelContinuous microinfusionHippocampal atrophyLobe epilepsyGlutamate excessNeuropathological featuresExtracellular glutamateHippocampal neuronsAnimal modelsTherapeutic interventionsHippocampusSeizuresSclerosisSynthetase deficiencyMinimal injuryPatientsRats