2020
Sex Difference In Kidney Electrolyte Transport III: Impact of Low K intake on Thiazide‐Sensitive Cation Excretion in Male and Female Mice
Xu S, Li J, Yang L, Wang C, Liu T, Weinstein A, Palmer L, Wang T. Sex Difference In Kidney Electrolyte Transport III: Impact of Low K intake on Thiazide‐Sensitive Cation Excretion in Male and Female Mice. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.04495.Peer-Reviewed Original ResearchNa-Cl co-transporterNa/H exchanger isoform 3Glomerular filtration rateFemale miceHigh K intakeUrine volumeENaC protein expressionCation excretionDietary potassium intakeLow K intakeIncreased Na transportSex differencesNCC abundanceThiazide-sensitiveNCC expressionNa/H exchangeNa reabsorptionNHE2 expressionPotassium intakeNCC proteinDistal nephronNCC activityK intakeFiltration rateMale mice
2019
Impact of High K Intake on Thiazide‐Sensitive Cation Excretion in Male and Female Wild‐type and AT1a Receptor Knockout Mice
Li J, Xu S, Wang C, Weinstein A, Palmer L, Wang T. Impact of High K Intake on Thiazide‐Sensitive Cation Excretion in Male and Female Wild‐type and AT1a Receptor Knockout Mice. The FASEB Journal 2019, 33: 864.4-864.4. DOI: 10.1096/fasebj.2019.33.1_supplement.864.4.Peer-Reviewed Original ResearchNa/H exchanger isoform 3Na-Cl co-transporterFemale wild-typeGlomerular filtration rateKO miceCation excretionNa/H exchangeDistal NaAng IIUrine volumeFemale miceThiazide-sensitive Na-Cl co-transporterApical membrane of distal tubulesAT1a receptor knockout miceHK dietWild-typeResponse to high KAT1a-KO miceK + excretionReceptor knockout miceDistal nephron segmentsFemale KO miceGroups of miceRenal clearance experimentsAT1A KO
2017
Regulation of glomerulotubular balance: flow-activated proximal tubule function
Wang T, Weinbaum S, Weinstein A. Regulation of glomerulotubular balance: flow-activated proximal tubule function. Pflügers Archiv - European Journal Of Physiology 2017, 469: 643-654. PMID: 28271233, PMCID: PMC6162058, DOI: 10.1007/s00424-017-1960-8.Peer-Reviewed Original ResearchConceptsNa/H exchanger isoform 3Proximal tubulesTubule functionIntracellular Ca2+ signalingProximal tubule transportMammalian proximal tubuleAcid-base transportersProximal tubule functionRegulation of sodiumCa2+ signalingHCO3- absorptionStimulate Na+Tubule transportMicropuncture studiesSolute reabsorptionPeritubular membraneBrush border membraneBrush border microvilliGlomerulotubular balanceHCO3- transportIsoform 3Flow velocity changesTubulesRegulatory mechanismsTransporter availability