2010
Shear stress-induced changes of membrane transporter localization and expression in mouse proximal tubule cells
Duan Y, Weinstein A, Weinbaum S, Wang T. Shear stress-induced changes of membrane transporter localization and expression in mouse proximal tubule cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 21860-21865. PMID: 21106755, PMCID: PMC3003103, DOI: 10.1073/pnas.1015751107.Peer-Reviewed Original ResearchConceptsProximal tubule cellsMouse proximal tubuleNa/K-ATPaseTubule cellsApical NHE3Proximal tubulesMouse proximal tubule cellsFSS-induced changesApical plasma membraneV-ATPaseAmount of protein expressionBasolateral membraneWestern blot analysisNHE3Volume reabsorptionTransporter expressionBasolateral transportProtein expressionMPT cellsShear stress-induced changesVacuolar H(+)-ATPaseBlock microtubule polymerizationControl cellsModulate cellular functionsTransporter localization
2007
Role of fluid shear stress in cytoskeleton reorganization of mouse proximal tubule epithelium
Duan Y, Du Z, Yan Q, Weinstein A, Weinbaum S, Wang T. Role of fluid shear stress in cytoskeleton reorganization of mouse proximal tubule epithelium. The FASEB Journal 2007, 21: a915-a915. DOI: 10.1096/fasebj.21.6.a915-a.Peer-Reviewed Original ResearchCytoskeleton reorganizationShear stressPeripheral actin networkCell-cell contactModulate cellular functionsTransmit mechanical forcesActin cytoskeletonActin networkCytoskeleton remodelingStress fibersF-actinCellular functionsVinculin expressionCytoskeletonZO-1Collagen substrateE-cadherinParallel plate flow chamberJunction-like structuresFluid shear stressShearFluid shearStrikingly different responsesCellsPT cells