High dietary K+ intake inhibits proximal tubule transport
Wang T, Liu T, Xu S, Frindt G, Weinstein A, Palmer L. High dietary K+ intake inhibits proximal tubule transport. American Journal Of Physiology. Renal Physiology 2023, 325: f224-f234. PMID: 37318989, PMCID: PMC10396284, DOI: 10.1152/ajprenal.00013.2023.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateFree-flow micropunctureUrine volumeFractional excretion of Na<sup>+</sup>Proximal tubulesFiltration rateFractional NaNephron segmentsExcretion of Na<sup>+</sup>Dietary K<sup>+</sup>NHE3 protein expressionExchanger isoform 3Increased urine volumeIncreased fractional excretionVolume reabsorptionAbsolute NaKidney functionProtein expressionIsoform 3PT transportAnesthetized animalsReabsorptionWestern blottingRatsExcretionHigh Dietary K Intake Inhibits Proximal Tubule Transport and Reduces GFR
Wang T, Liu T, Xu S, Frindt G, Palmer L, Weinstein A. High Dietary K Intake Inhibits Proximal Tubule Transport and Reduces GFR. Physiology 2023, 38: 5731363. DOI: 10.1152/physiol.2023.38.s1.5731363.Peer-Reviewed Original ResearchGlomerular filtration rateReduced glomerular filtration rateK + excretionProximal tubulesTubular fluidConnecting tubuleUrine volumeTreated ratsNephron segmentsReduction of glomerular filtration rateProximal tubule transportLengths of proximal tubulesDistal nephron segmentsProximal nephron segmentsFree-flow micropunctureNa + absorptionHK intakeIncreased FENaTubule transportFractional deliveryFiltration rateKidney functionIncreased secretionFluid absorptionFITC-inulin