2023
Association of Body Mass Index and Waist Circumference With Imaging Metrics of Brain Integrity and Functional Connectivity in Children Aged 9 to 10 Years in the US, 2016-2018
Kaltenhauser S, Weber C, Lin H, Mozayan A, Malhotra A, Constable R, Acosta J, Falcone G, Taylor S, Ment L, Sheth K, Payabvash S. Association of Body Mass Index and Waist Circumference With Imaging Metrics of Brain Integrity and Functional Connectivity in Children Aged 9 to 10 Years in the US, 2016-2018. JAMA Network Open 2023, 6: e2314193. PMID: 37200030, PMCID: PMC10196880, DOI: 10.1001/jamanetworkopen.2023.14193.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexWaist circumferenceBMI z-scoreCross-sectional studyBrain healthCross-sectional analysisFunctional connectivityMass indexMean ageInterval developmentCorpus callosumAssociation of BMIHigher baseline body mass indexBaseline cross-sectional analysisBaseline body mass indexBrain integrityResting-state functional connectivityLongitudinal analysisFuture treatment trialsABCD studyLower microstructural integrityCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyCardiovascular implications
2022
Coordinated anatomical and functional variability in the human brain during adolescence
Bero J, Li Y, Kumar A, Humphries C, Nag S, Lee H, Ahn W, Hahn S, Constable R, Kim H, Lee D. Coordinated anatomical and functional variability in the human brain during adolescence. Human Brain Mapping 2022, 44: 1767-1778. PMID: 36479851, PMCID: PMC9921246, DOI: 10.1002/hbm.26173.Peer-Reviewed Original ResearchConceptsCortical thicknessCortical areasFunctional connectivityResting-state functional connectivityAssociation cortical areasMultiple cortical areasCortical information processingAge-related changesCortical myelinationAdult brainCytoarchitectural featuresBrain developmentInformation processingBrainDevelopmental changesHuman brainAdolescenceMyelinationPatterns of coordinationMeasuresRegional variationMyelin
2020
Behavioral and brain signatures of substance use vulnerability in childhood
Rapuano KM, Rosenberg MD, Maza MT, Dennis NJ, Dorji M, Greene AS, Horien C, Scheinost D, Constable R, Casey BJ. Behavioral and brain signatures of substance use vulnerability in childhood. Developmental Cognitive Neuroscience 2020, 46: 100878. PMID: 33181393, PMCID: PMC7662869, DOI: 10.1016/j.dcn.2020.100878.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingSubstance useFunctional connectivityCognitive Development StudyFuture substance useSubstance use vulnerabilityAdolescent substance useSubstance use increasesSubstance use outcomesIndividual differencesAdolescent brainBrain signaturesTask conditionsBehavioral measuresFamilial risk factorsUse outcomesRisky behaviorsLatent dimensionsFamilial factorsBrain modelCurrent studyWeak predictorDevelopment studiesEarly susceptibilityFunctional imaging
2016
Language at rest: A longitudinal study of intrinsic functional connectivity in preterm children
Rowlands MA, Scheinost D, Lacadie C, Vohr B, Li F, Schneider KC, Constable R, Ment LR. Language at rest: A longitudinal study of intrinsic functional connectivity in preterm children. NeuroImage Clinical 2016, 11: 149-157. PMID: 26937383, PMCID: PMC4753807, DOI: 10.1016/j.nicl.2016.01.016.Peer-Reviewed Original ResearchConceptsLeft occipito-temporal cortexOccipito-temporal cortexVerbal IQPerformance IQLanguage deficitsSignificant connectivity reductionsPreterm childrenIntrinsic functional connectivityFull IQFunctional connectivity networksFunctional connectivityIQAge 8PT childrenConnectivity reductionLong-range connectionsWorse performanceLinear mixed effects modelsLongitudinal studyConnectivity networksAge 16PT subjectsTS childrenCortical connectivityTerm children
2001
Patterns of functional magnetic resonance imaging activation in association with structural lesions in the rolandic region: a classification system.
Carpentier A, Constable R, Schlosser M, de Lotbinière A, Piepmeier J, Spencer D, Awad I. Patterns of functional magnetic resonance imaging activation in association with structural lesions in the rolandic region: a classification system. Journal Of Neurosurgery 2001, 94: 946-54. PMID: 11409524, DOI: 10.3171/jns.2001.94.6.0946.Peer-Reviewed Original ResearchConceptsFMR imaging activationSurgical interventionRolandic regionMotor cortex plasticityMotor task paradigmFunctional magnetic resonance imagingMotor skillsMagnetic resonance imagingSevere motor impairmentFunctional magnetic resonanceFunctional recoveryLesion sideCortical abnormalitiesMotor cortexControl volunteersCortical malformationsStructural lesionsContralateral hemisphereArteriovenous malformationsBrain lesionsSurgical proceduresMotor impairmentPathological lesionsFunctional reorganizationAuthors' institution