2023
Blunted neural reward response to alcohol and greater alcohol motivation in binge drinkers in a randomized clinical experiment
Blaine S, Fogelman N, Lacadie C, Constable T, Sinha R. Blunted neural reward response to alcohol and greater alcohol motivation in binge drinkers in a randomized clinical experiment. Alcohol Clinical And Experimental Research 2023, 47: 1067-1078. PMID: 37070596, PMCID: PMC10289130, DOI: 10.1111/acer.15082.Peer-Reviewed Original ResearchAlcohol taste testFunctional magnetic resonance imagingAlcohol motivationSupplementary motor areaOrbitofrontal cortexInferior frontal gyrus regionsPerfusion functional magnetic resonance imagingEnhanced neural responseNeural reward responsesMedial orbitofrontal cortexPlacebo sessionAlcohol use disorderBrain reward regionsPlacebo-controlled effectsNeural processesOFC responsesReward responsesNeural responsesPlacebo beerSocial drinkersCerebral blood flowReward regionsBD relativeVentral striatumAlcohol effects
1997
An fMRI study of the human cortical motor system response to increasing functional demands
Wexler B, Fulbright R, Lacadie C, Skudlarski P, Kelz M, Constable R, Gore J. An fMRI study of the human cortical motor system response to increasing functional demands. Magnetic Resonance Imaging 1997, 15: 385-396. PMID: 9223039, DOI: 10.1016/s0730-725x(96)00232-9.Peer-Reviewed Original ResearchConceptsMotor-sensory areasSupplementary motor areaFunctional magnetic resonance imagingPremotor areasMotor areaMultiple motor areasComplexity of movementCortical motor systemRight-hand finger movementsIndex finger movementsFinger movementsMagnetic resonance imagingInferior parietal areasConsistent lateralizationResonance imagingBrain regionsActivation changesMotor system responsesParietal areasHand finger movementsPreliminary reproducibility studyFMRI studySignificant main effectWeek periodGreater increase