2024
Comprehension of English for‐adverbials: The Nature of Lexical Meanings and the Neurocognitive Architecture of Language
Piñango M, Lai Y, Deo A, Foster‐Hanson E, Lacadie C, Constable T. Comprehension of English for‐adverbials: The Nature of Lexical Meanings and the Neurocognitive Architecture of Language. Topics In Cognitive Science 2024 PMID: 39008778, DOI: 10.1111/tops.12746.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingArchitecture of languageLexical meaningSelf-paced readingConceptual systemNeurocognitive architectureLexical itemsConceptual representationDurative predicatesSyntactic compositionMeaning representationsProcessing profilesActivity patternsMagnetic resonance imagingSentencesConceptual structureResonance imagingIterative readingNeurocognitionLanguageMean compositionReadingComprehensionMeanItemsLow‐calorie diet‐induced weight loss is associated with altered brain connectivity and food desire in obesity
Hoang H, Lacadie C, Hwang J, Lam K, Elshafie A, Rosenberg S, Watt C, Sinha R, Constable R, Savoye M, Seo D, Belfort‐DeAguiar R. Low‐calorie diet‐induced weight loss is associated with altered brain connectivity and food desire in obesity. Obesity 2024, 32: 1362-1372. PMID: 38831482, PMCID: PMC11211061, DOI: 10.1002/oby.24046.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingIntrinsic connectivity distributionDiet-induced weight lossBrain connectivityAssociated with altered brain connectivityLow-calorie dietEating behavior changesShort-term low-calorie dietRight hippocampusTemporal cortexBrain networksWeight lossBrain clustersEffects of diet-induced weight lossGroup differencesFood desireGlucose levelsDiagnosis of type 2 diabetesBehavioral changesMagnetic resonance imagingType 2 diabetesBrainLeptin levelsFood intakeResonance imaging
2023
Challenges in fMRI and Its Limitations
Constable R. Challenges in fMRI and Its Limitations. 2023, 497-510. DOI: 10.1007/978-3-031-10909-6_22.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingBlunted neural reward response to alcohol and greater alcohol motivation in binge drinkers in a randomized clinical experiment
Blaine S, Fogelman N, Lacadie C, Constable T, Sinha R. Blunted neural reward response to alcohol and greater alcohol motivation in binge drinkers in a randomized clinical experiment. Alcohol Clinical And Experimental Research 2023, 47: 1067-1078. PMID: 37070596, PMCID: PMC10289130, DOI: 10.1111/acer.15082.Peer-Reviewed Original ResearchAlcohol taste testFunctional magnetic resonance imagingAlcohol motivationSupplementary motor areaOrbitofrontal cortexInferior frontal gyrus regionsPerfusion functional magnetic resonance imagingEnhanced neural responseNeural reward responsesMedial orbitofrontal cortexPlacebo sessionAlcohol use disorderBrain reward regionsPlacebo-controlled effectsNeural processesOFC responsesReward responsesNeural responsesPlacebo beerSocial drinkersCerebral blood flowReward regionsBD relativeVentral striatumAlcohol effects
2019
Chapter 4 The uniqueness of the individual functional connectome
Horien C, Scheinost D, Constable R. Chapter 4 The uniqueness of the individual functional connectome. 2019, 63-81. DOI: 10.1016/b978-0-12-813838-0.00004-2.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingIndividual differencesIndividual functional connectomesBrain functionConnectivity dataGroup-level differencesFunctional connectivity dataHuman neuroimagingBehavioral measuresFunctional connectomeMagnetic resonance imagingResonance imagingInterindividual heterogeneityNext turnConnectomeCognitionBest predictive modelNeuroimagingDifferencesParticipantsDisease
2018
Hyperinsulinemia Invokes Greater Brain Perfusion in Reward and Motivation Regions in Obesity
GROSKREUTZ D, SINHA R, LACADIE C, LAM W, HAMZA M, SCHMIDT C, SEO D, HWANG J, BELFORT-DEAGUIAR R, LEVENTHAL J, ROSENBERG S, PARIKH L, CONSTABLE T, SHERWIN R, JASTREBOFF A. Hyperinsulinemia Invokes Greater Brain Perfusion in Reward and Motivation Regions in Obesity. Diabetes 2018, 67 DOI: 10.2337/db18-365-or.Peer-Reviewed Original ResearchCerebral blood flowElevated insulin levelsInsulin levelsFunctional magnetic resonance imagingLean humansObese humansHour oral glucose tolerance testOral glucose tolerance testSetting of hyperinsulinemiaGlucose tolerance testEuglycemic hyperinsulinemic clampEffect of hyperinsulinemiaAnterior cingulate cortexMagnetic resonance imagingWhole-brain analysisFood-seeking behaviorMiddle temporal gyrusMannKind CorporationCBF responseCNS effectsSatiety factorTolerance testBrain perfusionOB groupLN group
2016
Individual variation in functional brain connectivity: implications for personalized approaches to psychiatric disease
Finn E, Constable R. Individual variation in functional brain connectivity: implications for personalized approaches to psychiatric disease. Dialogues In Clinical Neuroscience 2016, 18: 277-287. PMID: 27757062, PMCID: PMC5067145, DOI: 10.31887/dcns.2016.18.3/efinn.Peer-Reviewed Original ResearchConceptsFunctional brain connectivityFunctional magnetic resonance imagingFunctional brain connectionsBrain connectivityMagnetic resonance imagingFunctional connectivity profilesPsychiatric illnessHealthy subjectsFuture illnessPsychiatric diagnosisPsychiatric diseasesMental illnessResonance imagingSingle-subject levelInterindividual variabilityPersonalized approachFunctional connectivityBrain connectionsIllnessConnectivity profilesRecent evidenceReliable correlateBehavioral phenotypesNeural organizationSubjects
2011
Challenges in fMRI and Its Limitations
Constable R. Challenges in fMRI and Its Limitations. 2011, 331-344. DOI: 10.1007/978-1-4419-0345-7_19.Peer-Reviewed Original ResearchFunctional magnetic resonance imaging
2010
Challenges in fMRI and Its Limitations
Constable R. Challenges in fMRI and Its Limitations. 2010, 71-92. DOI: 10.1007/978-1-4419-1329-6_4.Peer-Reviewed Original ResearchFunctional magnetic resonance imaging
2009
Language lateralization in epilepsy patients: fMRI validated with the Wada procedure
Arora J, Pugh K, Westerveld M, Spencer S, Spencer DD, Constable R. Language lateralization in epilepsy patients: fMRI validated with the Wada procedure. Epilepsia 2009, 50: 2225-2241. PMID: 19490042, DOI: 10.1111/j.1528-1167.2009.02136.x.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingVerbal fluency taskWada procedureSentence comprehensionFluency taskLaterality scoresLanguage lateralizationLaterality indexAuditory sentence comprehensionFMRI language mappingAuditory taskReading taskConjunction analysisHemispheric dominanceLateralization scoresFMRI laterality indicesLanguage mappingWada testingMidline regionWada testLateralizationSpecific patient examplesQuantifying activationTaskComprehension
2008
Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing
Canli T, Congdon E, Constable R, Lesch K. Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing. Biological Psychology 2008, 79: 118-125. PMID: 18314252, DOI: 10.1016/j.biopsycho.2008.01.004.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingEvent-related potentialsNeutral facial expressionsSpecific neural lociWord stimuliEmotional scenesAffective processingAffective stimuliEmotional stimuliVerbal stimuliNeural correlatesIndividual differencesNeural processingNeural locusBrain responsesFacial expressionsConvergent evidenceIndependent study samplesFMRI dataRobust effectCortical regionsStimuliTPH2 genotypeTryptophan hydroxylase 2 geneCurrent study
2007
Applications and limitations of whole‐brain MAGIC VASO functional imaging
Scouten A, Constable R. Applications and limitations of whole‐brain MAGIC VASO functional imaging. Magnetic Resonance In Medicine 2007, 58: 306-315. PMID: 17654574, PMCID: PMC2673534, DOI: 10.1002/mrm.21273.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingCerebrospinal fluidBlood Oxygenation Level Dependent (BOLD) imagesAuditory stimulationWhole-brain functional magnetic resonance imagingActivation-induced decreaseCerebral blood volumeMagnetic resonance imagingSuperior temporal gyrusBlood volumeThree-compartment modelResonance imagingCSF contributionTemporal gyrusFunctional imagingVisual stimulation
2005
Disturbed Coupling of rCBF, BOLD and CMRO2 in the Presence of Stimuli During Anesthesia As Revealed by Simultaneous BOLD and CBF Functional Magnetic Resonance Imaging
Qiu M, Ramani R, Shulman R, Hyder F, Rajeevan N, Constable R. Disturbed Coupling of rCBF, BOLD and CMRO2 in the Presence of Stimuli During Anesthesia As Revealed by Simultaneous BOLD and CBF Functional Magnetic Resonance Imaging. Journal Of Neurosurgical Anesthesiology 2005, 17: 224-225. DOI: 10.1097/01.ana.0000187715.47773.67.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingMagnetic resonance imagingDisturbed couplingSimultaneous BOLDResonance imagingPresence of stimuliCMRO2AnesthesiaRCBFBOLD
2004
Attentional bias for valenced stimuli as a function of personality in the dot-probe task
Amin Z, Constable R, Canli T. Attentional bias for valenced stimuli as a function of personality in the dot-probe task. Journal Of Research In Personality 2004, 38: 15-23. DOI: 10.1016/j.jrp.2003.09.011.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingAttentional biasAttentional tasksDot-probe taskDimensions of affectFunction of personalityDimensions of personalityValenced stimuliAttentional probeEmotional stimuliNegative affectFusiform gyrusVisual searchGreater activationAutonomic arousalBrain regionsVisual fieldTaskAffectPersonalityIncreased effortStimuliMagnetic resonance imagingBiasNeuroticism
2001
Functional MRI of Language Processing: Dependence on Input Modality and Temporal Lobe Epilepsy
Carpentier A, Pugh K, Westerveld M, Studholme C, Skrinjar O, Thompson J, Spencer D, Constable R. Functional MRI of Language Processing: Dependence on Input Modality and Temporal Lobe Epilepsy. Epilepsia 2001, 42: 1241-1254. PMID: 11737158, DOI: 10.1046/j.1528-1157.2001.35500.x.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingAuditory language taskLanguage tasksLanguage processingTask presentationLateralization scoresLanguage comprehension taskVisual language taskModality-specific areasInput modalitiesDifferent input modalitiesMagnetic resonance imagingTemporal lobe epilepsy patientsFMRI resultsBA 44FMRI findingsAuditory inputBroca's areaLanguage areasNeuropsychological testingVisual inputFMRI dataWada testingLanguage localizationAbstract dimensionsPatterns of functional magnetic resonance imaging activation in association with structural lesions in the rolandic region: a classification system.
Carpentier A, Constable R, Schlosser M, de Lotbinière A, Piepmeier J, Spencer D, Awad I. Patterns of functional magnetic resonance imaging activation in association with structural lesions in the rolandic region: a classification system. Journal Of Neurosurgery 2001, 94: 946-54. PMID: 11409524, DOI: 10.3171/jns.2001.94.6.0946.Peer-Reviewed Original ResearchConceptsFMR imaging activationSurgical interventionRolandic regionMotor cortex plasticityMotor task paradigmFunctional magnetic resonance imagingMotor skillsMagnetic resonance imagingSevere motor impairmentFunctional magnetic resonanceFunctional recoveryLesion sideCortical abnormalitiesMotor cortexControl volunteersCortical malformationsStructural lesionsContralateral hemisphereArteriovenous malformationsBrain lesionsSurgical proceduresMotor impairmentPathological lesionsFunctional reorganizationAuthors' institution
2000
Network analysis of brain activations in working memory: Behavior and age relationships
Mencl W, Pugh K, Shaywitz S, Shaywitz B, Fulbright R, Constable R, Skudlarski P, Katz L, Marchione K, Lacadie C, Gore J. Network analysis of brain activations in working memory: Behavior and age relationships. Microscopy Research And Technique 2000, 51: 64-74. PMID: 11002354, DOI: 10.1002/1097-0029(20001001)51:1<64::aid-jemt7>3.0.co;2-d.Peer-Reviewed Original ResearchConceptsMedial temporal lobeFunctional magnetic resonance imagingBrain activationTemporal lobeBetter memory performanceInferior frontal gyrusRight medial temporal lobeRight prefrontal regionsMedial frontal cortexInferior temporal lobeMemory recognitionMemory testMemory performanceInferior frontalPrefrontal regionsFrontal gyrusNew stimuliExtrastriate cortexRehearsal periodMemory impairmentBrain scoreOlder subjectsVisual formAge effectsRecognition periodEffect of Estrogen on Brain Activation Patterns in Postmenopausal Women During Working Memory Tasks
Shaywitz S, Shaywitz B, Pugh K, Fulbright R, Skudlarski P, Mencl W, Constable R, Naftolin F, Palter S, Marchione K, Katz L, Shankweiler D, Fletcher J, Lacadie C, Keltz M, Gore J. Effect of Estrogen on Brain Activation Patterns in Postmenopausal Women During Working Memory Tasks. Obstetrical & Gynecological Survey 2000, 55: 227-228. DOI: 10.1097/00006254-200004000-00021.Peer-Reviewed Original ResearchBrain activation patternsSuperior frontal gyrusMemory taskFrontal gyrusCognitive functionActivation patternsPronounceable nonsense wordsVerbal memory taskFunctional magnetic resonance imagingWorking Memory TaskRight superior frontal gyrusFunctional magnetic resonanceInferior parietal lobuleVerbal storageNonverbal stimuliNonsense wordsStimulus typeParietal lobuleLeft hemisphereRight hemisphereEffects of estrogenTamil lettersPlacebo conditionMagnetic resonance imagingRetrieval tasks
1997
Predicting Reading Performance From Neuroimaging Profiles: The Cerebral Basis of Phonological Effects in Printed Word Identification
Pugh K, Shaywitz B, Shaywitz S, Shankweiler D, Katz L, Fletcher J, Skudlarski P, Fulbright R, Constable R, Bronen R, Lacadie C, Gore J. Predicting Reading Performance From Neuroimaging Profiles: The Cerebral Basis of Phonological Effects in Printed Word Identification. Journal Of Experimental Psychology Human Perception & Performance 1997, 23: 299-318. PMID: 9103996, DOI: 10.1037/0096-1523.23.2.299.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingPhonological effectsLexical decision taskLexical decision latenciesLexical-semantic processesBrain activation patternsWord identificationWord recognitionDecision taskDecision latenciesRegularity effectIndividual differencesFMRI measuresHemispheric lateralizationCerebral basisExperimental paradigmActivation patternsCortical regionsLength effectYoung adultsTaskParticipantsReadingMeasuresMagnetic resonance imagingAn fMRI study of the human cortical motor system response to increasing functional demands
Wexler B, Fulbright R, Lacadie C, Skudlarski P, Kelz M, Constable R, Gore J. An fMRI study of the human cortical motor system response to increasing functional demands. Magnetic Resonance Imaging 1997, 15: 385-396. PMID: 9223039, DOI: 10.1016/s0730-725x(96)00232-9.Peer-Reviewed Original ResearchConceptsMotor-sensory areasSupplementary motor areaFunctional magnetic resonance imagingPremotor areasMotor areaMultiple motor areasComplexity of movementCortical motor systemRight-hand finger movementsIndex finger movementsFinger movementsMagnetic resonance imagingInferior parietal areasConsistent lateralizationResonance imagingBrain regionsActivation changesMotor system responsesParietal areasHand finger movementsPreliminary reproducibility studyFMRI studySignificant main effectWeek periodGreater increase