2023
Pyroptosis in cardiovascular diseases: Pumping gasdermin on the fire
Yarovinsky T, Su M, Chen C, Xiang Y, Tang W, Hwa J. Pyroptosis in cardiovascular diseases: Pumping gasdermin on the fire. Seminars In Immunology 2023, 69: 101809. PMID: 37478801, PMCID: PMC10528349, DOI: 10.1016/j.smim.2023.101809.Peer-Reviewed Original ResearchConceptsPost-translational modificationsAcute cardiovascular eventsChronic cardiovascular diseaseCardiovascular diseaseSmall molecule inhibitorsPyroptosis resultsGenetic toolsGasdermin proteinsWhole organismInflammatory caspasesCardiovascular eventsCell deathMolecule inhibitorsCell typesProteolytic cleavageCellular mechanismsActivation of inflammasomesCardiovascular systemKnockout animalsAmplification of inflammationRole of pyroptosisPro-inflammatory processesDifferent cellsNovel therapeutic approachesPyroptosis
2000
Expression of the protein tyrosine phosphatase, phosphatase of regenerating liver 1, in the outer segments of primate cone photoreceptors
Yarovinsky T, Rickman D, Diamond R, Taub R, Hageman G, Rickman C. Expression of the protein tyrosine phosphatase, phosphatase of regenerating liver 1, in the outer segments of primate cone photoreceptors. Brain Research 2000, 77: 95-103. PMID: 10814835, DOI: 10.1016/s0169-328x(00)00045-0.Peer-Reviewed Original ResearchConceptsProtein tyrosine phosphatasePRL-1 genePRL-1Regenerating Liver-1Tyrosine phosphataseSingle mRNA speciesAmino acid sequencePRL-1 mRNAPrimate cone photoreceptorsPhotoreceptor cell functionImmediate early genesUnique transcriptsCone photoreceptor cellsCone photoreceptorsCDNA clonesMRNA speciesAcid sequenceAffinity-purified antibodiesOuter segmentsEarly genesSouthern blotGenesHigh abundanceChromosome 6qPhosphatase activity