2023
Immune Modulation of Innate and Adaptive Responses Restores Immune Surveillance and Establishes Antitumor Immunologic Memory.
Alvero A, Fox A, Madina B, Krady M, Gogoi R, Chehade H, Nakaar V, Almassian B, Yarovinsky T, Rutherford T, Mor G. Immune Modulation of Innate and Adaptive Responses Restores Immune Surveillance and Establishes Antitumor Immunologic Memory. Cancer Immunology Research 2023, 12: 261-274. PMID: 38078853, PMCID: PMC11027955, DOI: 10.1158/2326-6066.cir-23-0127.Peer-Reviewed Original ResearchPD-L1Immunological memoryImmune surveillanceLong-term anti-tumor effectsAnti-tumor immunological memoryAnti-tumor immune responseImmune modulatory capacityAnti-tumor responseOvarian cancer patientsAnti-tumoral responseAnti-tumor effectsImmune regulatory genesSelf-amplifying RNAVirus-like vesiclesPotent CD8MDSC expansionAdaptive armsCurrent immunotherapiesOncolytic capacityPrevent recurrenceAntitumor cytokinesCancer patientsImmune modulationImmune modulatorsOncolytic effectCancer immunotherapy with enveloped self-amplifying mRNA CARG-2020 that modulates IL-12, IL-17 and PD-L1 pathways to prevent tumor recurrence
Chen J, Madina B, Ahmadi E, Yarovinsky T, Krady M, Meehan E, Wang I, Ye X, Pitmon E, Ma X, Almassian B, Nakaar V, Wang K. Cancer immunotherapy with enveloped self-amplifying mRNA CARG-2020 that modulates IL-12, IL-17 and PD-L1 pathways to prevent tumor recurrence. Acta Pharmaceutica Sinica B 2023, 14: 335-349. PMID: 38261838, PMCID: PMC10792965, DOI: 10.1016/j.apsb.2023.08.034.Peer-Reviewed Original ResearchCancer immunotherapyTumor recurrenceShort hairpin RNASurvival benefitIL-12Immune mechanismsLong-term survival benefitIL-17 receptor ACancer-promoting inflammationLarge established tumorsMultiple immune mechanismsPD-L1 pathwayT cell exhaustionDeath ligand 1Human cancer immunotherapySelf-amplifying mRNATumor-bearing miceVirus-like vesiclesMechanism of protectionCombined immunomodulationContralateral tumorsIL-17Established tumorsAbscopal effectImmunological memory
2019
Virus-like Vesicles Expressing Multiple Antigens for Immunotherapy of Chronic Hepatitis B
Yarovinsky TO, Mason SW, Menon M, Krady MM, Haslip M, Madina BR, Ma X, Moshkani S, Chiale C, Pal AC, Almassian B, Rose JK, Robek MD, Nakaar V. Virus-like Vesicles Expressing Multiple Antigens for Immunotherapy of Chronic Hepatitis B. IScience 2019, 21: 391-402. PMID: 31704650, PMCID: PMC6889364, DOI: 10.1016/j.isci.2019.10.040.Peer-Reviewed Original ResearchHepatitis B virusChronic hepatitis BHepatitis BSerum HBV surface antigenVirus-like vesiclesLiver HBV RNAPersistent HBV replicationHBV surface antigenImmune exhaustionChronic hepatitisHBV antigensHBV infectionBooster immunizationCD8 TChronic modelHBV replicationImmunotherapeutic approachesLiver injuryNaive miceHBV RNAB virusCurrent treatmentSurface antigenUnmet needMultiple antigens