2023
Pyroptosis in cardiovascular diseases: Pumping gasdermin on the fire
Yarovinsky T, Su M, Chen C, Xiang Y, Tang W, Hwa J. Pyroptosis in cardiovascular diseases: Pumping gasdermin on the fire. Seminars In Immunology 2023, 69: 101809. PMID: 37478801, PMCID: PMC10528349, DOI: 10.1016/j.smim.2023.101809.Peer-Reviewed Original ResearchConceptsPost-translational modificationsAcute cardiovascular eventsChronic cardiovascular diseaseCardiovascular diseaseSmall molecule inhibitorsPyroptosis resultsGenetic toolsGasdermin proteinsWhole organismInflammatory caspasesCardiovascular eventsCell deathMolecule inhibitorsCell typesProteolytic cleavageCellular mechanismsActivation of inflammasomesCardiovascular systemKnockout animalsAmplification of inflammationRole of pyroptosisPro-inflammatory processesDifferent cellsNovel therapeutic approachesPyroptosis
2001
Lung fibroblasts inhibit activation-induced death of T cells through PGE2-dependent mechanisms
Yarovinsky T, Hunninghake G. Lung fibroblasts inhibit activation-induced death of T cells through PGE2-dependent mechanisms. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2001, 281: l1248-l1256. PMID: 11597917, DOI: 10.1152/ajplung.2001.281.5.l1248.Peer-Reviewed Original ResearchConceptsActivation-induced cell deathFibroblast-conditioned mediumT cellsLung fibroblastsFas/Fas ligand-dependent mechanismFas ligand-dependent mechanismMouse primary lung fibroblastsPGE2-dependent mechanismsImmobilized anti-CD3 antibodyAnti-CD3 antibodyActivation-induced deathPrimary lung fibroblastsLigand-dependent mechanismTreatment of fibroblastsCaspase-3Fas receptorAntiapoptotic activityIndomethacinCell deathInhibitory activityFibroblastsDeathFibroblast culturesCaspase-8Cells