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Thuy Tran, MD, PhD

Assistant Professor of Medicine (Medical Oncology)
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About

Titles

Assistant Professor of Medicine (Medical Oncology)

Biography

Dr. Tran is an Assistant Professor of Medicine (Medical Oncology) and cares for patients with melanoma and other advanced skin cancers at the Smilow Cancer Hospital in New Haven and in Smilow Guilford. She participated in the ABIM Physician-Scientist Research Pathway and completed both her internal medicine residency and hematology/oncology clinical fellowship at Yale.  She received her MD and PhD degrees from Vanderbilt University School of Medicine. 

Dr. Tran is actively engaged in translational research in melanoma brain metastases and developing novel therapeutics and drug combinations to improve responses in melanoma and overcome immune resistance.  She has been funded through the Yale Cancer Center T32, the YCC K12 Calabresi Immuno-Oncology Training Program (IOTP), and the Skin Cancer SPORE career enhancement program.  Dr. Tran is the principal investigator of several clinical trials in melanoma.

Appointments

Other Departments & Organizations

Education & Training

Clinical Fellow
Yale-New Haven Hospital (2019)
Resident
Yale-New Haven Hospital (2015)
MD
Vanderbilt University School of Medicine (2013)
PhD
Vanderbilt University School of Medicine, Department of Pathology, Microbiology, and Immunology (2011)
BS
Emory University, Biology and French (2005)

Research

Overview

As a physician-scientist and clinical investigator, my hope is to be able to move bench research efficiency to the clinic. Most importantly, I want to learn from the patients and their experience to inform my studies. My ultimate goal is to improve immune treatment options and quality of life for patients with metastatic malignancies.

My research focuses on understanding and improving clinical targets to overcome resistance to immune therapy.  We are actively engaged in studies related to macrophage migration inhibitor factor (MIF) in melanoma as well as understanding complications from brain metastatic disease.  I have focused on addressing neurologic complications of brain metastases or its treatment by (1) identifying mediators of metastasis-associated edema that can be given concurrently to further improve brain-active systemic therapies and patient outcomes, (2) identifying key immune cells driving radiation necrosis after treatment with stereotactic radiosurgery, and (3) determining key brain tumor infiltrating immune cell subsets and evaluating their effect on patient response and survival.  



Medical Research Interests

Blood-Brain Barrier; Clinical Trials as Topic; Drug Combinations; Immune Checkpoint Proteins; Melanoma; Neoplasm Metastasis

Research at a Glance

Yale Co-Authors

Frequent collaborators of Thuy Tran's published research.

Publications

2024

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Clinical Trials

Current Trials

Clinical Care

Overview

Clinical Specialties

Melanoma and Onco-Dermatology; Medical Oncology

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