2016
Whole-exome sequencing in obsessive-compulsive disorder identifies rare mutations in immunological and neurodevelopmental pathways
Cappi C, Brentani H, Lima L, Sanders SJ, Zai G, Diniz BJ, Reis VN, Hounie AG, Conceição do Rosário M, Mariani D, Requena GL, Puga R, Souza-Duran FL, Shavitt RG, Pauls DL, Miguel EC, Fernandez TV. Whole-exome sequencing in obsessive-compulsive disorder identifies rare mutations in immunological and neurodevelopmental pathways. Translational Psychiatry 2016, 6: e764-e764. PMID: 27023170, PMCID: PMC4872454, DOI: 10.1038/tp.2016.30.Peer-Reviewed Original ResearchConceptsSingle nucleotide variantsPPI networkPathway analysisProtein-protein interaction networkGenome-wide association studiesNovo single nucleotide variantsParticular biological pathwaysRare genetic variationDisease gene prioritizationDirect molecular interactionWhole-exome sequencing studiesGene discoveryNetwork genesSpecific risk genesNetwork enrichmentGenetic variationInteraction networksGene prioritizationCandidate genesAssociation studiesBiological pathwaysSequencing platformsSequencing studiesWhole-exome sequencingGenes
2013
Gene variants associated with antisocial behaviour: a latent variable approach
Bentley MJ, Lin H, Fernandez TV, Lee M, Yrigollen CM, Pakstis AJ, Katsovich L, Olds DL, Grigorenko EL, Leckman JF. Gene variants associated with antisocial behaviour: a latent variable approach. Journal Of Child Psychology And Psychiatry 2013, 54: 1074-1085. PMID: 23822756, PMCID: PMC3766409, DOI: 10.1111/jcpp.12109.Peer-Reviewed Original ResearchConceptsRisk allelesGenetic risk allelesSingle nucleotide polymorphismsGene variantsNurse home visitation programAge 15 yearsStress response pathwaysCholinergic signalingDrug useCommon genetic variantsPutative risk allelesAntisocial behaviorVariable scoresResponse pathwaysGenetic polymorphismsVisitation programMolecular networksPathway analysisStress responseGenesGenetic variablesMolecular levelGenetic variants