Hydroxypropylcyclodextrins in parenteral use. II: Effects on transport and disposition of lipids in rabbit and humans
Irie T, Fukunaga K, Garwood M, Carpenter T, Pitha J, Pitha J. Hydroxypropylcyclodextrins in parenteral use. II: Effects on transport and disposition of lipids in rabbit and humans. Journal Of Pharmaceutical Sciences 1992, 81: 524-528. PMID: 1522488, DOI: 10.1002/jps.2600810610.Peer-Reviewed Original ResearchConceptsTotal cholesterolHyperlipidemic Watanabe rabbitsOnly untoward effectSingle intravenous administrationProximal convoluted tubulesDisposition of lipidsIntravenous infusionHypervitaminosis ARepeated administrationThoracic aortaWatanabe rabbitsIntravenous administrationUntoward effectsAtherosclerotic lesionsSingle injectionConvoluted tubulesParenteral administrationParenteral useCholesterolAdministrationSlight reliefPatientsInfusionRabbitsHydroxypropyl-beta