Surveillance for Early Detection of Aggressive Parathyroid Disease: Carcinoma and Atypical Adenoma in Familial Isolated Hyperparathyroidism Associated With a Germline HRPT2 Mutation1*
Kelly TG, Shattuck TM, Reyes‐Mugica M, Stewart AF, Simonds WF, Udelsman R, Arnold A, Carpenter TO. Surveillance for Early Detection of Aggressive Parathyroid Disease: Carcinoma and Atypical Adenoma in Familial Isolated Hyperparathyroidism Associated With a Germline HRPT2 Mutation1*. Journal Of Bone And Mineral Research 2006, 21: 1666-1671. PMID: 16995822, DOI: 10.1359/jbmr.060702.Peer-Reviewed Original ResearchMeSH KeywordsAdenomaBase SequenceCarcinomaChildGenetic TestingGerm-Line MutationHumansHyperparathyroidism, PrimaryMaleMolecular Sequence DataParathyroid NeoplasmsTumor Suppressor ProteinsConceptsGermline HRPT2 mutationsHRPT2 mutationsPrimary hyperparathyroidismEarly detectionParathyroid tumorsFamilial hyperparathyroid syndromesAggressive histological featuresSpecific surveillance strategiesMalignant parathyroid tumorsGenetic screeningLeukocyte DNA analysisMutations of HRPT2FIHP familiesHyperparathyroidism AssociatedParathyroid statusRecurrent diseaseClassic tumor suppressor geneBiochemical surveillanceLeft neckRare causeAggressive featuresInitial tumorParathyroid diseaseSurgical extirpationPatients 7